In the isoquinoline ring system of the title mol-ecule, C(16)H(16)N(2)O(5), the N-heterocyclic ring is in a half-boat conformation. The dioxaaza-spiro ring is essentially planar [maximum deviation = 0.022 (1) Å] and forms a dihedral angle of 24.56 (4)° with the benzene ring.

Phytochemical profile of the Central American rainforest endemic Annonaceae species, Annona pittieri and Cymbonopetallum costaricense, were studied in search novel bioactive compounds. The acetogenin squamocin (1) isolated from A. showed cytotoxic activity against human acute lymphocytic leukaemia with low healthy blood cells. In addition, other eight compounds pittieri, including a 2-azaanthra...

A new series of anti-cancer agents based on 1,2-diaryl-5,6-dihydropyrrolo[2,1-a]isoquinoline scaffold containing N,N-diethylamino‌ethoxy, piperidinyl‌ethoxy or morpholinyl‌ethoxy group at the para position of the C-2 phenyl ring were synthesized and their cytotoxic activities were assessed against several human cancer cell lines including MCF-7 (ER positive breast cancer cell), MDA-MB231 (ER-ne...

Berberine is a phytogenic isoquinoline alkaloid which demonstrates several pharmacological effects, including hypoglycemic effect. Its medical use limited by its very low bioavailability. Synthesizing new berberine derivatives might help in overcoming this problem. In work, we report on the synthesis and biological evaluation of novel 9-O-derivative. At an oral dose 25 mg/kg, compound demonstra...

Berberine is a natural isoquinoline alkaloid with significant antitumor activity against many types of cancer cells, including ovarian tumors. This study investigated the molecular mechanisms by which berberine differently affects cell growth of cisplatin (cDDP)-sensitive and -resistant and polyamine analogue cross-resistant human ovarian cancer cells. The results show that berberine suppresses...

Very few of the more than sixty naturally-occurring isoquinoline alkaloids have been screened for pharmacological activity, although certain members of this class have known hallucinogenic and cardiovascular activity. Recently the suggestion that biosynthetic catecholamine-derived tetrahydroisoquinolines are involved in the etiology of alcoholism has stimulated research into their activity. Bot...