Malaria is perhaps the most important parasitic infection and strongest known force for selection in the recent evolutionary history of the human genome. Genetically-determined resistance to malaria has been well-documented in some populations, mainly from Africa. The disease is also endemic in South Asia, the world's second most populous region, where resistance to malaria has also been observ...

The standard model of cosmology, based on what has come to be called the Friedmann-Lemaitre-Robertson-Walker (FLRW) model (hereinafter simply the Friedmann model), is now part of scientific culture. The most popular current version leads to the hot big bang (HBB) description events near the beginning of the cosmic expansion, which has often been called a creation2 moment at the beginning of phy...

The aim of this study was to determine the influences of polymorph systems such as hemoglobin and transferrin types on some the reproduction traits in Norduz goats. The material of this study consisted of 65 Norduz goats. The polymorphism of hemoglobin and transferrin phenotypes of Norduz goats were determined. Blood proteins were analyzed through horizontal starch gel electrophoresis. It was f...

Methanol (MeOH) is considered to be a poison in humans because of the alcohol dehydrogenase (ADH)-mediated conversion of MeOH to formaldehyde (FA), which is toxic. Our recent genome-wide analysis of the mouse brain demonstrated that an increase in endogenous MeOH after ADH inhibition led to a significant increase in the plasma MeOH concentration and a modification of mRNA synthesis. These findi...

BACKGROUND Fetal hemoglobin level is a heritable complex trait that strongly correlates swith the clinical severity of sickle cell disease. Only few genetic loci have been identified as robustly associated with fetal hemoglobin in patients with sickle cell disease, primarily adults. The sole approved pharmacologic therapy for this disease is hydroxyurea, with effects largely attributable to ind...

Abdominal pain is one of the most common reasons why people seek medical care, and is often due to spasm of intra-abdominal visceral organs. Hyoscine butylbromide (HBB) is a quaternary ammonium compound which blocks the action of acetylcholine at parasympathetic sites (both muscarinic and nicotinic receptors) in smooth muscle, and in secretory glands. It causes decreased motility of the gastroi...

Depressive-like behaviors in animals are usually assessed by standardized behavioral tests such as the forced swimming test (FST). However, individual variation in test performance may obscure group differences and thereby hinder the discovery of genes responsible for depression. Few reports have shown the influence of individual variability in identifying the genes associated with depressive-l...

Congenital defects of bile acid synthesis are rare disorders that cause progressive liver dysfunction. We present a case alpha methylacyl-CoA racemase (AMACR) deficiency with non-spherocytic hemolytic anemia who presented rapidly severe cholestasis and failure normal gamma-glutamyl transferase levels. After extensive investigation, he was found to have AMACR HBB gene mutation associated possibl...

The identification of human body fluids or tissues through mRNA-based profiling is very useful for forensic investigations. Previous studies have shown mRNA biomarkers are effective to identify the origin of biological samples. In this study, we selected 16 tissue specific biomarkers to evaluate their specificities and sensitivities for human body fluids and tissues identification, including po...