In the mol-ecular structure of the title compound, C(11)H(10)ClNO(3), the conformation of the N-H bond in the amide segment is syn to the ortho-methyl group in the phenyl ring. The C=O and O-H bonds of the acid group are in the relatively rare anti position with respect to each other. This is an obvious consequence of the hydrogen bond donated to the amide carbonyl group. The central oxobutenoi...

Heparanase is overexpressed in many solid tumor cells and is capable of specifically cleaving heparan sulfate, and this activity is associated with the metastatic potential of tumor cells; however, the activation mechanism of heparanase has remained unknown. In this study, we investigated the link between disulfide bond formation and the activation of heparanase in human tumor cells. Mass spect...

The part of credit spread that is not explained by corporate credit risk forecasts future economic activity. I show that the link with aggregate business risk and bond liquidity risk explains this finding. Once I project spreads on these two risk factors, which are readily measurable with the daily frequency, in addition to corporate credit risk, the forecasting power of the residual spread red...

The title compound, C(18)H(18)FN(3)O(2), adopts a trans conformation with respect to the C=N double bond. The dihedral angle between the two benzene rings is: 59.73 (6)°. Two independent N-H⋯O hydrogen bonds link the mol-ecules into layers parallel to (101).

In the title mol-ecule, C(18)H(12)O(4), the phenyl ring is twisted by 23.2 (1)° from the mean plane of the chromene system. In the crystal, weak inter-molecular C-H⋯O hydrogen bonds link mol-ecules into zigzag chains extending in the [010] direction. An intra-molecular O-H⋯O hydrogen bond is also present.

In the title compound, C(14)H(12)ClNO, the meta-methyl substituent in the aniline ring is positioned anti to the N-H bond. The dihedral angle between the rings is 12.4 (1)°. The crystal structure is stabilized by inter-molecular N-H⋯O hydrogen bonds, which link the mol-ecules into C(4) chains running along the c-axis direction.

The complete mol-ecule of the title compound, C(6)H(12)N(2)O(5), is generated by a rotation about a twofold axis. The conformation along the bond sequence linking the two amino groups is trans-trans-(+)gauche-trans-trans. In the crystal, N-H⋯O hydrogen bonds link the mol-ecules into a three-dimensional supra-molecular architecture.

The characteristic feature of the title mol-ecule, C16H23NO4, is the syn configuration of the partially double amide C-N bond [C-N-C-O torsion angle = -14.8 (2)°]. The crystal packing is determined by inter-molecular O-H⋯O and N-H⋯O hydrogen bonds, which link the mol-ecules into a double-chain structure extending along [010].

In the title mol-ecule, C(12)H(10)N(2)O(3), the aromatic and furan rings form a dihedral angle of 8.89 (1)° and an intra-molecular N-H⋯O hydrogen bond occurs. In the crystal structure, inter-molecular O-H⋯O hydrogen bonds link the mol-ecules into zigzag chains running along the c axis.

The asymmetric unit of the title compound, C(8)H(8)N(4)O(2), contains one half-mol-ecule; a twofold rotation axis bisects the molecule. An intra-molecular N-H⋯O hydrogen bond results in the formation of a five-membered ring, which displays an envelope conformation. In the crystal structure, inter-molecular O-H⋯N hydrogen bonds link the mol-ecules.