Chromatin from two Syrian hamster tissues: the Kirkman-Robbins hepatoma and the liver, has been separated into soluble (S) and insoluble (P) fractions. Both fractions contain the complete set of five main histones but differ in respect of H1 subfractions. The hepatoma chromatin is known to contain an unusual H1 subfraction, H1 slow [12, 13], probably identical with a similar subfraction present...

Histones H1 or linker histones are highly dynamic proteins that diffuse throughout the cell nucleus and associate with chromatin (DNA and associated proteins). This binding interaction of histone H1 with the chromatin is thought to regulate chromatin organization and DNA accessibility to transcription factors and has been proven to involve a kinetic process characterized by a population that as...

Antibodies directed against whole histone and purified lysine-rich histone H1 extracted f rom isolated macronuclei of the ciliate Tetrahymena were obtained and conjugated to fluorescein isothiocyanate. The fluorescein-antibody conjugates were used to directly label Tetrahymena cells. Both macroand micronuclei were visibly fluorescent in cells stained with anti-whole histone conjugate. However ,...

BACKGROUND Switching or reclassifying medicines with established safety profiles from prescription to non-prescription aims to increase timely consumer access to medicines, reduce under-treatment and enhance self-management. However, risks include suboptimal therapy and adverse effects. With a long-standing government policy supporting switching or reclassifying medicines from prescription to n...

Abstract. We study the convergence of the upwind Finite Volume scheme applied to the linear advection equation with a Lipschitz divergence-free speed in Rd . We prove a h1/2−ε-error estimate in the L∞(Rd × [0, T ])-norm for Lipschitz initial data. The expected optimal result is a h1/2-error estimate. In a second part, we also prove a h1/2-error estimate in the L(0, T ; L2(Rd))-norm for initial ...

Given that a time-delay system is stable for some delay h0 > 0, a procedure is given to find the stability interval [h1, h ∗ 2] such that h0 ∈ [h1, h2] and for all h satisfying h1 < h < h ∗ 2 the system is stable. Further, the system is shown to be unstable if h = h1 or h = h ∗ 2. It is then shown how this can be applied to test the robust stability (with respect to delay values) of a Smith-Pre...

Human RNase H1 cleaves RNA only when the RNA is present in a DNA-RNA heteroduplex. Previous efforts to create RNase H1 knockout mice resulted in embryonic lethality1, but demonstrated that RNase H1 is required for mitochondrial function. We constructed viable constitutive hepatocyte liver specific RNase H1 knock out mice by coupling the Cre recombinase to an albumin promoter as albumin is not e...