Abnormalities in cardiomyocyte Ca2+ handling contribute to impaired contractile function in heart failure (HF). Experiments on single ryanodine receptors (RyRs) incorporated into lipid bilayers have indicated that RyRs from failing hearts are more active than those from healthy hearts. Here, we analyzed spontaneous Ca2+ sparks (brief, localized increased in [Ca2+]i) to evaluate RyR cluster acti...

ALKindy Col Med J 2015:Vol. 11 No. 2 69 www.kmjub.com Abstract: Background: No previous Iraqi study was done on the estimation of post mortem interval (PMI) from the medico-legal point of view; depending on the biochemical changes of vitreous humor. Objectives: To find out the relationship between some biochemical changes in vitreous humor and post mortem interval. To find out a new formula for...

PCI [1] , which underscores the need to monitor patients post-PCI and to develop therapeutic strategies to combat PMI. The assessment of circulating biomarkers such as troponin I or T and creatine kinase-MB (CK-MB) following PCI has become an important clinical tool for the identification of patients at risk for the development of PMI [1, 3, 4] . For example, a rise in circulating CK-MB levels ...

This article discusses post-merger integration (PMI) and the trade-off between the economic benefits and costs that arise when organizations merge under a new organizational structure and reconfigure their businesses and resources. To reconfiguration scholars, PMI is a crucial tool for firms to reconfigure resources, product lines, and business units to adjust to internal and external environme...

Pointwise mutual information (PMI), a simple measure of lexical association, is part of several algorithms used as models of lexical semantic memory. Typically, it is used as a component of more complex distributional models rather than in isolation. We show that when two simple techniques are applied—(1) down-weighting co-occurrences involving lowfrequency words in order to address PMI’s so-ca...

In this in-depth, qualitative case study, we elucidate how the emotions of middle managers impact their sensemaking and sensegiving practices during post-merger integration (PMI). The recursive reciprocal interactions between emotions, sensemaking, observed led to development a process model illustrating make sense PMI phase through processes “senseseeking” “rationalizing.” further demonstrates...

BACKGROUND One of the primary control measures for malaria transmission is indoor residual spraying (IRS). Historically, few women have worked in IRS programs, despite the income-generating potential. Increasing women's roles in IRS requires understanding the barriers to women's participation and implementing measures to address them. The U.S. President's Malaria Initiative (PMI) Africa Indoor ...