Effects of epidermal growth factor (EGF) and an antibody (Ab-528) reactive against the binding site for EGF on human EGF receptors were studied on multicellular tumor spheroids obtained from three human glioma cell lines with high (D-37 MG), medium (D-247 MG), and low (D-263 MG) levels of EGF receptor expression. The D-247 MG and D-263 MG spheroids grew slowly or not at all in the absence of EG...

BACKGROUND The antimicrobial peptide LL-37 is a significant molecule of innate immunity and recent studies indicate that it plays an important role in maintaining oral health. Yet limited knowledge exists on its role in oral diseases and oral lichen planus (OLP) in particular. OBJECTIVE The study aimed to examine: 1) the salivary concentration of LL-37 in patients with OLP and healthy subject...

Periodontal diseases are inflammatory conditions that affect the supporting tissues of teeth and can lead to destruction of the bone support and ultimately tooth loss if untreated. Progression of periodontitis is usually site specific but not uniform, and currently there are no accurate clinical methods for distinguishing sites where there is active disease progression from sites that are quies...

The psyllid Diaphorina citri Kuwayama (Hemiptera: Psyllidae) is one of the most important pests of citrus worldwide because it efficiently vectors three bacteria in the genus Candidatus Liberibacter that cause the devastating citrus greening disease (huanglongbing). Current management practices for this insect pest rely on multiple sprays of foliar insecticides and one or two applications of so...

Recent work in supervised learning has shown that a surprisingly simple Bayesian classiier with strong assumptions of independence among features, called naive Bayes, is competitive with state-of-the-art classiiers such as C4.5. This fact raises the question of whether a classiier with less restrictive assumptions can perform even better. In this paper we evaluate approaches for inducing classi...

Here we report the development of a gene-synthesis technology, circular assembly amplification. In this approach, we first constructed exonuclease-resistant circular DNA via simultaneous ligation of oligonucleotides. Exonucleaseand subsequent mismatch cleaving endonuclease–mediated degradation of the resulting ligation mixture eliminated error-rich products, thereby substantially improving gene...

Decision-making about innovative change in high-risk networks is exceptionally difficult because system failure may result in catastrophe. We adopt a historical method to compare the US and Soviet choices in their nuclear attack submarine programs between 1970 and 1996 and to surface their complex political, technological, and operational relations. One program achieved high reliability in the ...