BACKGROUND Thalamic dysfunction has been implicated in obsessive-compulsive disorder (OCD). While OCD frequently has its onset during childhood, to our knowledge, no prior study has measured neuroanatomical changes in the thalamus of patients with OCD near the onset of illness, and before and after treatment. METHODS Volumetric magnetic resonance imaging studies were conducted in 21 psychotro...

BACKGROUND Hyperactivity of the anterior cingulate cortex (ACC) in patients with obsessive-compulsive disorder (OCD) has been shown to increase with symptom provocation and to normalize with treatment-induced symptom reduction. Although the functional significance of anterior cingulate involvement in OCD remains unknown, electrophysiological evidence has linked this region to error-processing a...

OBJECTIVE Evidence suggests that early-onset obsessive-compulsive disorder (OCD) is an etiologically distinct subtype of OCD. The objective of the present work was to search for neurocognitive endophenotypes of early-onset OCD based on assessments of attention, memory, and executive function in patients with the disorder and their unaffected siblings. METHODS We compared the performance of 40...

Although Obsessive-Compulsive Disorder (OCD) and Depression are classified as separate disorders, the high incidence of co-morbidity and the strong correlations between measures of each has led to debate about the nature of their relationship. Some authors have proposed that OCD is in fact a mood disorder while others have suggested that the two disorders are grounded in negative affectivity. A...

objective: the present study aimed to explore the relationship between worry and obsessive compulsive symptoms. we examined the correlations between the padua inventory (pi) and the penn state worry questionnaire (pswq) to further explore the distinctiveness of the pi. method: seventy-five subjects (n=40 male, n= 35 female) were selected from hafez hospital (iran) for this study: the subjects i...

objective: the present study aimed to investigate the metacognitive model of obsessive-compulsive disorder (ocd), through a comparative study of thought fusion beliefs and thought control strategies between patients with ocd, depression, and normal people. methods: this is a causal-comparative study. about 20 patients were selected with ocd, and 20 patients with major depression disorder (mdd),...

There is compelling evidence to implicate dopamine in the etiology of obsessive compulsive disorder (OCD). Administration of amphetamine (Ellinwood, 1967) phenmetrazine and L dopa produces obsessive symptoms. Furthermore, a recent study indicated in Tourette's syndrome patients, fluvoxamine worsened tics, coprolalia and OCD but the addition of pimozide improved both OCD and tics (McDougle et al...

PURPOSE Femoral osteochondritis dissecans (OCD) is a disorder of unknown aetiology and variable prognosis that causes knee pain. In this paper, the authors study the impact of lower limb malalignment on the development and prognosis of OCD. METHODS After anteroposterior (AP) and lateral radiograph and MRI of the knee, 53 cases of OCD were diagnosed. All patients were studied by standing full-...

BACKGROUND Pathological gambling (PG) and obsessive-compulsive disorder (OCD) are conceptualized as a behavioral addiction, with a dependency on repetitive gambling behavior and rewarding effects following compulsive behavior, respectively. However, no neuroimaging studies to date have examined reward circuitry during the anticipation phase of reward in PG compared with in OCD while considering...