multiple sclerosis (ms) is an autoimmune inflammatory, demyelinating disease of human central nervous system. experimental autoimmune encephalomyelitis (eae) is the commonly used animal model of ms. calorie restriction has been found to reduce inflammation and autoimmune responses and promote neuroprotection. in this study we evaluated the effects of intermittent feeding protocol of the calorie...

BACKGROUND In intra-arterial (IA) thrombolysis trials, higher rates of symptomatic intracerebral haemorrhage (sICH) were found than in trials with intravenous (IV) recombinant tissue plasminogen activator (tPA); this observation could have been due to the inclusion of more severely affected patients in IA thrombolysis trials. In the present study, we investigated the rate of sICH in IA and comb...

INTRODUCTION This study aims to describe the perceptions of orthopedic surgeons on the efficacy of intra-articular hyaluronic acid (IA-HA), the influence of IA-HA product characteristics on its efficacy, and to identify patterns and factors related to the use of IA-HA. Additionally, this study examines factors that influence IA-HA brand selection, focusing on Euflexxa(®) (1% sodium hyaluronate)...

Glucocorticoids rapidly stimulate endocannabinoid synthesis and modulation of synaptic transmission in hypothalamic neuroendocrine cells via a nongenomic signaling mechanism. The endocannabinoid actions are synapse-constrained by astrocyte restriction of extracellular spatial domains. Exogenous cannabinoids have been shown to modulate postsynaptic potassium currents, including the A-type potass...

The monoclonal antibodies (mAb) DA6.147, DA6.164, and HIG.48 against human Ia antigens, but not the W6/32 mAb against human class I major histocompatibility complex antigens or the anti-monocyte OKM1 and 63D3 mAb, stimulated monocytes to secrete interleukin 1 (IL-1). IL-1 was measured by its property of promoting the production of interleukin 2 (IL-2) by phytohemagglutinin-treated LBRM-33 clone...

We present new evolutionary models for Type Ia supernova (SN Ia) progenitors, where we include massstripping effect on a main-sequence (MS) or slightly evolved companion star by winds from a mass-accreting white dwarf (WD). The mass-stripping attenuates the rate of mass transfer from the companion to the WD. As a result, quite a massive MS companion can avoid forming a common envelope to increa...

Monosynaptic connections between muscle spindle (Ia) afferents and motoneurons (MNs), the central portion of the stretch reflex circuit, are highly specific, but the mechanisms underlying this specificity are primarily unknown. In this study, we report that embryonic overexpression of neurotrophin-3 (NT3) in muscles disrupts the development of these specific Ia-MN connections, using transgenic ...

The iron mass in galaxy clusters is about 6 times larger than could have been produced by core-collapse SNe, assuming the stars in cluster galaxies formed with a standard IMF. Type-Ia SNe have been proposed as the alternative dominant iron source. We use our HST measurements of the cluster SN-Ia rate at high redshift to study the cluster iron enrichment scenario. The measurements can constrain ...

Over the past decades, Information Access (IA) tasks have evolved and diversified. For example, in the mid20th century, Information Retrieval (IR) was about set retrieval for libraries; then with the advent of the digital information overload era, ranked retrieval became a necessity; now in the 21st century, we are experiencing richer forms of IR such as diversified Web search in order to satis...