نتایج جستجو برای: آنزیم na k atpase

تعداد نتایج: 652131  

2016
Yanling Yan Muhammad A. Chaudhry Steven T. Haller Christopher A. Drummond David J. Kennedy

Background-—We have demonstrated that cardiotonic steroids, such as ouabain, signaling through the Na/K-ATPase, regulate sodium reabsorption in the renal proximal tubule. By direct carbonylation modification of the Pro222 residue in the actuator (A) domain of pig Na/K-ATPase a1 subunit, reactive oxygen species are required for ouabain-stimulated Na/K-ATPase/c-Src signaling and subsequent regula...

2014
Emmanuelle Berret Pascal Y. Smith Mélaine Henry Denis Soulet Sébastien S. Hébert Katalin Toth Didier Mouginot Guy Drolet

MnPO neurons play a critical role in hydromineral homeostasis regulation by acting as sensors of extracellular sodium concentration ([Na(+)]out). The mechanism underlying Na(+)-sensing involves Na(+)-flow through the NaX channel, directly regulated by the Na(+)/K(+)-ATPase α1-isoform which controls Na(+)-influx by modulating channel permeability. Together, these two partners form a complex invo...

Journal: :Frontiers in bioscience : a journal and virtual library 2005
Zijian Xie Joe Xie

The Na/K-ATPase, or Na+ pump, is a member of the P-type ATPase superfamily. In addition to pumping ions, the Na/K-ATPase is a receptor that not only regulates the function of protein kinases, but also acts as a scaffold, capable of tethering different proteins into a signalplex. The signaling Na/K-ATPase resides in caveolae and forms a "binary receptor" with the tyrosine kinase Src. Endogenous ...

Journal: :American journal of physiology. Renal physiology 1998
Ulla Holtbäck Yoshiyuki Ohtomo Petter Förberg Bo Sahlgren Anita Aperia

Renal sympathetic nerves play a central role in the regulation of tubular Na+ reabsorption. Norepinephrine (NE) and neuropeptide Y (NPY) are colocalized in renal sympathetic nerve endings. The purpose of this study is to examine the integrated effects of these neurotransmitters on the regulation of Na+-K+-ATPase, the enzyme responsible for active Na+ reabsorption in renal tubular cells. Studies...

Journal: :Gerontology 2002
Hikmet Koçak Pernur Oner Baria Oztaş

BACKGROUND Na(+),K(+)-ATPase is known to be responsible for the ionic homeostasis in excitable tissues. The energy cost of Na(+),K(+)-ATPase activity is increased in the active brain, so it would be important to ascertain whether defects in brain metabolism in aging are associated with changes in the properties of Na(+),K(+)-ATPase. OBJECTIVE The aim of this study was to investigate the influ...

Journal: :The Journal of neuroscience : the official journal of the Society for Neuroscience 2003
Marina S Feschenko Claudia Donnet Randall K Wetzel Natalya K Asinovski Larry R Jones Kathleen J Sweadner

Phospholemman (FXYD1) is a homolog of the Na,K-ATPase gamma subunit (FXYD2), a small accessory protein that modulates ATPase activity. Here we show that phospholemman is highly expressed in selected structures in the CNS. It is most abundant in cerebellum, where it was detected in the molecular layer, in Purkinje neurons, and in axons traversing the granule cell layer. Phospholemman was particu...

Journal: :American journal of physiology. Renal physiology 2008
Sandrine V Pierre Yoann Sottejeau Jean-Michel Gourbeau Gladis Sánchez Amjad Shidyak Gustavo Blanco

The ion transporter Na-K-ATPase functions as a cell signal transducer that mediates ouabain-induced activation of protein kinases, such as ERK. While Na-K-ATPase composed of the alpha(1)-polypeptide is involved in cell signaling, the role of other alpha-isoforms (alpha(2), alpha(3), and alpha(4)) in transmitting ouabain effects is unknown. We have explored this using baculovirus-directed expres...

2016
Dan Cheng Mingxing Feng Yufei Ji Wenjun Wu Zhaonong Hu

Na(+)/K(+)-ATPase (sodium pump) is an important target for the development of botanical pesticide as it is responsible for transforming chemical energy in ATP to osmotic work and maintaining electrochemical Na(+ )and K(+ )gradients across the cell membrane of most animal cells. Celangulin IV (C-IV) and V (C-V), which are isolated from the root bark of Celastrus angulatus, are the major active i...

Journal: :Physiological research 2009
A Reyes M M Galindo L García D Segura-Pena C Caruso-Neves A Eblen-Zajjur T Proverbio R Marín F Proverbio

Rhythmic daily changes in the Na,K-ATPase activity have been previously described for rat kidney cortex, showing two peaks: at 0900 h and 2100 h, and two valleys: at 1500 h and 0100 h -0300 h. The oscillations in Na,K-ATPase activity are produced by an inhibitor, which binds the enzyme and is present in the rat blood plasma at valley times and absent or at very low concentrations at peak times....

Journal: :Cancer research 1990
B Zheng K Oishi M Shoji H Eibl W E Berdel J Hajdu W R Vogler J F Kuo

The effects and modes of action of certain antineoplastic phospholipid analogues (racemic 1-O-octadecyl-2-O-methyl glycero-3-phosphocholine, BM 41.440, JH-1, CV-3988, and HePC) on (sodium plus potassium)-activated adenosine triphosphatase (Na,K-ATPase) and sodium pump activities were investigated. Inhibition of Na,K-ATPase in purified rat brain synaptosomal membranes by these lipids, in contras...

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