پیرو یافتن تک‌یاخته­ی Hepatozoon canis و نماتود Cercopithifilaria bainae در سگ­های ایران، این مطالعه با هدف تشخیص ناقلین بالقوه­ی دو انگل میان کنه­های جمع­آوری شده از ۵ استان ایران انجام شد. مهر ماه 1397 تا خرداد 1401 تعداد 222 قلاده سگ صاحبدار 541 ولگرد استان­های­ همدان (305 قلاده)، کرمانشاه (227 یزد (80 خوزستان (71 قلاده) مازندران جهت آلودگی به کنه­ مورد بررسی قرار گرفتند. جمع آوری (3339 عدد)...

It is now widely accepted that animal behavior optimizes certain performance criteria. The question is, which criteria are being optimized? To answer this question, today, ethologists start by conducting some exploratory experiments. After the preliminary data is gathered, they infer a set of potential hypotheses. In order to find out which hypothesis is more likely to be correct, they have to ...

Bacteria are able to sense their environment and move towards sources of attractant and away from sources of repellent through the process of chemotaxis. The best understood model for chemotaxis comes from Escherichia coli, where the biochemical pathways have been extensively studied. In E. coli, the bacterium switches between swimming and tumbling based on the changes in the local concentratio...

An in silico tool that can be utilized in the clinic to predict neoplastic progression and propose individualized treatment strategies is the holy grail of computational tumor modeling. Building such a tool requires the development and successful integration of a number of biophysical and mathematical models. In this paper, we work toward this long-term goal by formulating a cellular automaton ...

In pharmaceutical industry ligand based approaches like scaffold hopping, scaffold decoration and me-too approaches, are used to generate lead structures in discovery projects. We use several tools to generate novel lead structures, such as BROOD [1]. BROOD is a software tool which explores chemical space around query molecules based on shape similarity and electrostatics, and it generates anal...

Cancer is one of the causes of death in the world. Several treatment methods exist against cancer cells such as radiotherapy and chemotherapy. Since traditional methods have side effects on normal cells and are expensive, identification and developing a new method to cancer therapy is very important. Antimicrobial peptides, present in a wide variety of organisms, such as plants, amphibians and ...

In this study, an in silico genome-scale metabolic model of steroidogenesis was used to investigate the effects of hypoxic stress on steroid hormone productions in fish. Adult female fathead minnows (Pimephales promelas) were exposed to hypoxia for 7 days with fish sub-sampled on days 1, 3 and 7 of exposure. At each time point, selected steroid enzyme gene expressions and steroid hormone produc...