BACKGROUND This study was designed to assess the effects of a modified cardiopulmonary resuscitation (CPR) technique that consists of both active compression and active decompression of the chest (ACD CPR) versus standard CPR (STD CPR) on myocardial and cerebral blood flow during ventricular fibrillation both before and after epinephrine administration. METHODS AND RESULTS During a 30-second ...

A genetic mouse model (designated cardiomyocyte-Cpr-null) with cardiomyocyte-specific deletion of the cytochrome P450 (P450) reductase (Cpr) gene was generated in this study. CPR protein levels, as well the enzyme activity of P450s, were greatly reduced in heart microsomes from the null mice compared with wild-type mice, whereas CPR expression in other organs remained unchanged. Nonetheless, ho...

The conjunctival oxygen tension (CjO2) sensor is a non-invasive, continuous index of oxygen delivery in the haemodynamically unstable patient. Human and animal studies have indicated that CjO2 reflects cerebral blood flow and oxygenation. Simple insertion, rapid stabilization and reaction time less than 60 s allow use in the initial stages of cardiopulmonary resuscitation (CPR) where invasive m...

BACKGROUND Sustained compression is recommended to maximize myocardial and cerebral blood flow during cardiopulmonary resuscitation (CPR) in adults and children. We compared myocardial and cerebral perfusion during CPR in three groups of 2-week-old anesthetized swine using compression rates and duty cycles (duration of compression/total cycle time) of 100 per minute, 60%; 100 per minute, 30%; a...

OBJECTIVES In lay persons and health care providers performing cardiopulmonary resuscitation (CPR), does the use of CPR feedback/prompt devices when compared to no device improve CPR skill acquisition, retention, and real life performance? METHODS The Cochrane database of systematic reviews; Medline (1950-Dec 2008); EmBASE (1988-Dec 2008) and Psychinfo (1988-Dec 2008) were searched using ("Pr...

this survey, evaluated the level of awareness and knowledge among the medical staff about conditions and methods of performing cardiopulmonary ressucitation. the study sampling comprised 497 subjects including 208 residents and 262 interns of ten university hospitals in tehran. in regard to the basic principles, this has been 43.54% (sd = 13.36%), in drug and fluid therapy 31.22% (gd = 13.22%),...

Cardiopulmonary Resuscitation (CPR) is a simple and effective medical treatment for sudden cardiac arrest patients. Because of those existing interferences in the experiments, most of the animal experiments and the CPRs in vivo studies get contradictory conclusions. In this report, according to the current theories of CPR, we got a CPR model; simulated various CPR technologies, and compared the...

BACKGROUND Unlike Resuscitation Guidelines (GL) 2000, GL2005 advise resuming cardiopulmonary resuscitation (CPR) immediately after defibrillation. We hypothesized that immediate CPR resumption promotes earlier recurrence of ventricular fibrillation (VF). METHODS AND RESULTS This study used data of a prospective per-patient randomized controlled trial. Automated external defibrillators used by...

Introduction The implementation of creative new strategies to increase layperson cardiopulmonary resuscitation (CPR) and defibrillation may improve resuscitation in priority populations. As more communities implement laws requiring CPR training in high schools, there is potential for a multiplier effect and reach into priority communities with low bystander-CPR rates. Methods We investigated ...

OBJECTIVES Cardiopulmonary resuscitation (CPR) is a crucial yet weak link in the chain of survival for out-of-hospital cardiac arrest. We sought to understand the determinants of bystander CPR and the factors associated with successful training. METHODS For this systematic review, we searched 11 electronic databases, 1 trial registry and 9 scientific websites. We performed hand searches and c...