The pro-inflammatory cytokine, TNF-α, which plays a major role in the development and persistence of inflammatory diseases, is the basis for the use of anti-TNF-α therapies. The neutralization of TNF-α or blockage of its binding to the corresponding receptor has mainly served as a therapeutic strategy against some diseases. This study aimed to investigate the production of a humanized single ch...

Objective(s): To observe and determine the effect and mechanism of psoralen on tumor necrosis factor-α (TNF-α)-induced muscle atrophy.Materials and Methods: Three sets of C2C12 cells, including blank control, TNF-α (10 or 20 ng/ml) treatment and a TNF-α (10 or 20 ng/ml) plus psoralen (80 μM) administration were investigated. Cell viabili...

Background: According to previous studies, the effectiveness of interleukin-17 (IL-17) inhibitors was higher in anti-TNF-naïve patients with ankylosing spondylitis (AS) [1,2]. Netakimab (NTK) is a humanized anti-IL-17A antibody approved for treatment AS, psoriatic arthritis, moderate-to-severe plaque psoriasis Russia and Belarus. Objectives: To compare efficacy NTK anti-TNF-experienced active A...

Abstract Background Our previous studies reveal that impaired draining function of the synovial lymphatic vessel (LV) contributes to pathogenesis inflammatory arthritis, but cellular and molecular mechanisms involved are not fully understood. Objective To investigate involvement muscle cells (LMCs) in mediating LV arthritis. Methods TNF transgenic (TNF-Tg) arthritic mice were used. The structur...

Tumornekrosefaktor-Inhibitoren (TNF) spielen bei der Behandlung von rheumatoider Arthritis (RA) und Psoriasis-Arthritis (PsA) eine zentrale Rolle. Angesichts ihrer immunsuppressiven Wirkung sind schwere Infektionen im Zusammenhang mit TNF-Behandlung jedoch ein Problem. Christensen et al. evaluierten verglichen die Häufigkeit Patienten RA PsA, TNF behandelt wurden.

Tumor necrosis factor alpha (TNF-α) expression amplifies to excess amounts in several disorders such as rheumatoid arthritis and psoriasis. Although, Anti-TNF biologics have revolutionized the treatment of these autoimmune diseases, formation of anti-drug antibodies (ADA) has dramatically affected their use. The next generation antibodies (e.g. Fab, scFv) have not only reduced resulted immunoge...

TNFα is an inflammatory cytokine and the caspase and apoptotic processes can be activated by TNFα There are two classes of TNFα (solTNF and tmTNFα) which are important from the receptor aspect, so that solTNFα and tmTNFα can attach to the TNFR1, but tmTNFα just attaches to the TNFR2. Microglia cells are resident immune cells of the central nervous ...

introduction: effects of immediate tnf-α exposure on phenotype and function of dendritic cells (dcs) derived from cord blood mono nuclear cells materials and methods: umbilical cord blood mncs were isolated from healthy mothers and were divided into tnf(+( and tnf (-) groups. both were cultured using scf, flt3l, gm-csf and il-4. but, three ng/ml of tnf-α was first added in the culture of tnf(+(...