One of the most useful and apparently straightforward attributes of annular darkfield (ADF) STEM imaging is the ability to image heavy atoms on relatively light substrates using Z-contrast (High-Angle ADF) imaging. From multislice calculations, however, some isolated heavy atoms, e.g. Re, can go undetected in a thin Co matrix in standard aberrationcorrected HAADF-STEM imaging of catalyst nanopa...

We investigate for 26 OECD economies if their current account imbalances are driven by stochastic trends. Standard ADF results are contrasted with tests accounting for the bounded support of the current account. Neglecting the latter feature might give misleading results in the sense that ADF based conclusions are biased towards the rejection of unit root features. The current account imbalance...

Calorie restriction (CR) produces several health benefits and increases lifespan in many species. Studies suggest that alternate-day fasting (ADF) and exercise can also provide these benefits. Whether CR results in lifespan extension in humans is not known and a direct investigation is not feasible. However, phenotypes observed in CR animals when compared to ad libitum fed (AL) animals, includi...

Because the olfactory system plays a major role in food consumption, and because 'food addiction' and associated morbidities have reached epidemic proportions, we tested the hypothesis that dietary energy restriction can modify adverse effects of cocaine on behavior and olfactory cellular and molecular plasticity. Mice maintained on an alternate day fasting (ADF) diet exhibited increased baseli...

OBJECTIVE: Obesity is a worldwide health problem, with increasing prevalence associated with an increased risk of chronic diseases. Decrease in energy intake has been shown to lower the risk of coronary artery disease (CAD) in obese. The common form of dietary restriction is daily calorie restriction (CR). Another form is alternate-day fasting (ADF). The ability of modified ADF to facilitate we...

Six steers (BW = 436 +/- 15 kg) were assigned randomly to alfalfa, bromegrass, or prairie hay diets in a replicated 3 x 3 Latin square design to evaluate the efficacy of different internal markers for estimating OM digestibility (OMD). Internal markers used to estimate OMD included ADL, alkaline peroxide lignin (APL), AIA, and indigestible ADF (IADF), which consisted of a 144-h in vitro incubat...

This article evaluates abuse-deterrent formulations (ADFs) as a method to reduce prescription drug abuse while ensuring access to vital medications for individuals with legitimate need; assesses the pros and cons of ADFs and the current state of ADF adoption in the market; and develops policy recommendations to transition the market to ADFs. Although abuse-deterrent technology is still in its n...

Whether a cell is harnessing actin polymerization to produce movement, preparing for cytokinesis, or assembling long-lived actin filament-based structures such as sarcomeres or microvilli, actin polymerization must be controlled in time and space. Changes in actin organization often occur on a time scale that dictates an intimate coupling of a signal transduction apparatus to the machinery that...

Cell motility depends on the rapid assembly, aging, severing, and disassembly of actin filaments in spatially distinct zones. How a set of actin regulatory proteins that sustains actin-based force generation during motility work together in space and time remains poorly understood. We present our study of the distribution and dynamics of Arp2/3 complex, capping protein (CP), and actin-depolymer...