OBJECTIVE Little information is available about echocardiographic progression of mitral stenosis (MS). The aim of this study was to investigate whether the left ventricular (LV) strain is a favorable method predicting the progression of MS. METHODS Forty-eight patients with isolated mild-to-moderate MS were enrolled in this prospective cohort study. LV global longitudinal strain (GLS) and str...

We provide a feasible generalized least squares estimator for (unrestricted) multivariate GARCH(1,1) models. We show that the estimator is consistent and asymptotically normally distributed under mild assumptions. Unlike the (quasi) maximum likelihood method, the feasible GLS is considerably fast to implement and does not require any complex optimization routine. We present numerical experiment...

Peelle’s Pertinent Puzzle (PPP) was described in 1987 in the context of estimating fundamental parameters that arise in nuclear interaction experiments. In PPP, generalized least squares (GLS) parameter estimates fell outside the range of the data, which has raised concerns that GLS is somehow flawed and has led to suggested alternatives to GLS estimators. However, there have been no correspond...

Abstract Comparative methods are widely used in ecology and evolution. The most frequently used comparative methods are based on an explicit evolutionary model. However, recent approaches have been popularized that are without an evolutionary basis or an underlying null model. Here we highlight the limitations of such techniques in comparative analyses by using simulations to compare two common...

OBJECTIVE We explored cardiac volumes and the effects on systolic function in hypertrophic cardiomyopathy (HCM) patients with left ventricular hypertrophy (HCM LVH+) and genotype-positive patients without left ventricular hypertrophy (HCM LVH-). METHODS We included 180 HCM LVH+, 100 HCM LVH- patients and 80 healthy individuals. End-Diastolic Volume Index (EDVI), End-Systolic Volume Index (ESV...

Background Global longitudinal strain (GLS), has shown utility in detecting early subclinical LV dysfunction and has demonstrated significant efficacy in evaluating patients for chemotherapy cardiotoxicity. However, echocardiography is often reliant on operator experience and adequate quality windows for assessment. CMR is not subject to limitations of poor image quality due to its superior end...

Cellular signaling pathways exhibit complex response profiles with features such as thresholds and steep activation (i.e., ultrasensitivity). In a reconstituted mitotic spindle orientation pathway, activation of Drosophila Pins (LGN in mammals) by Gαi is ultrasensitive (apparent Hill coefficient of 3.1), such that Pins recruitment of the microtubule binding protein Mud (NuMA) occurs over a very...

Many graph search algorithms use a labeling of the vertices to compute an ordering of the vertices. We generalize this idea by devising a general vertex labeling algorithmic process called General Label Search (GLS), which uses a labeling structure which, when specified, defines specific algorithms. We characterize the vertex orderings computable by the basic types of searches in terms of prope...

A series of allosteric kidney-type glutaminase (GLS) inhibitors were designed and synthesized using 1,4-di(5-amino-1,3,4-thiadiazol-2-yl)butane as a core scaffold. A variety of modified phenylacetyl groups were incorporated into the 5-amino group of the two thiadiazole rings in an attempt to facilitate additional binding interactions with the allosteric binding site of GLS. Among the newly synt...

BACKGROUND With improved survival of patients undergoing primary bioprosthetic aortic valve replacement (AVR), reoperation to relieve severe prosthetic aortic stenosis (PAS) is increasing. Timing of redo surgery in asymptomatic/minimally symptomatic patients remains controversial. Left ventricular (LV) global longitudinal strain (GLS) is a marker of subclinical LV dysfunction. In asymptomatic/m...