PURPOSE The main advantage of administering chemotherapy by means of hepatic arterial infusion (HAI) is the achievement of a high concentration of the drug in the liver. Irinotecan (CPT-11) is an active agent for the treatment of advanced colorectal cancer and other tumor types, which frequently metastasize in the liver. We performed a Phase I and pharmacokinetic study to investigate CPT-11 by ...

Deoxyguanosine (dG) enhances the S phase cytotoxicity of camptothecin (CPT), a topoisomerase I (topo I) inhibitor, but by contrast does not affect the toxicity of VM26, a topoisomerase II inhibitor. The 80% survival of S phase human fibroblasts after a 60 min exposure to 0.2 microM CPT is reduced by half in the presence of 25 microM dG. G1 cells are resistant to CPT toxicity, though the levels ...

X-ray repair cross-complementing gene I protein (XRCC1) in complex with DNA polymerase beta, DNA ligase III, and poly(ADP-ribose) polymerase is important in the base excision repair process. Previously, we isolated camptothecin (CPT)-resistant cell lines (KB100 and KB300) from the human epidermoid carcinoma cell line KB by exposure to CPT. From these CPT-resistant cell lines, their revertants (...

This talk summarizes some theoretical features and experimental implications of a general Lorentz-violating extension of the minimal SU(3) × SU(2)× U(1) standard model that allows for both CPT-even and CPT-odd effects. The theory would arise as the low-energy limit of a fundamental theory that is Lorentz and CPT covariant but in which spontaneous Lorentz breaking occurs. The use of neutral-meso...

Background Echo and nuclear studies have shown that coronary flow changes with the cold pressor test (CPT). CPT has been used to measure coronary flow response because it provides an endothelium-dependent coronary vasodilation that is sensitive for detecting early changes in coronary endothelial function. There was also a study showed myocardial perfusion increases during CPT with first pass pe...

Liver microsomes contain two carnitine acyltransferase activities. One of these has properties closely corresponding to those of 88 kDa mitochondrial carnitine palmitoyltransferase-1 (CPT-1). Antisera against CPT-1 cross-react with an 88 kDa microsomal protein, suggesting that CPT-1 may be targeted to both microsomal and mitochondrial membranes. However, no experiments using cDNAs corresponding...

We present a general model-independent and rephase-invariant formalism that cleanly relates CP and CPT noninvariant observables to the fundamental parameters. Different types of CP and CPT violations in the K0-, B0-, B0 s and D 0-systems are explicitly defined. Their importance for interpreting experimental measurements of CP and CPT violations is emphasized. In particular, we show that the tim...

BACKGROUND The four-herb Chinese medicine PHY906(KD018) has been shown to both enhance the in vivo antitumor activity of irinotecan (CPT-11) against colon cancer tumor allografts and alleviate intestinal toxicity caused by CPT-11. METHODS Since intestinal bacteria can metabolize CPT-11 and PHY906, we investigated whether intestinal bacteria play a critical role in the in vivo activity of PHY9...