Benzocaine is a local anesthetic used for different pain treatments. Including it in various cyclodextrins one can increase the solubility of this drug. Several inclusion compounds of β-cyclodextrin (β-CD) with benzocaine, prepared by kneading and coprecipitation methods, were investigated. In order to understand the inclusion process mechanisms FT IR spectroscopic investigation and molecular m...

A fluorescence based cholesterol detection method has been developed using competitive host-guest interaction between graphene bound β-cyclodextrin (β-CD) with rhodamine 6G (R6G) and cholesterol. Fluorescence of β-CD incorporated R6G is quenched by graphene but is 'turned on' by cholesterol as it replaces R6G from the β-CD host.

New psychoactive substances (NPS) count as substances, which are slightly modified compared to illicit drugs regarding their chemical structure circumvent law. Compared classical such heroin, cocaine, or amphetamine, they show similar effects, however, because of novelty there is few knowledge about side effects toxicity. NPS available different substance classes, among them chiral novel deriva...

Abstract Datura stramonium L. (Solanaceae) possesses a rich tropane alkaloids (TAs) spectrum. The plant contains, in particular, the allelopathic compounds scopolamine and atropine, which are poorly soluble water, thus limiting their use agrochemical formulations as biocidal deterrent agents against herbivore insects. efficacy of hydrophobic TAs extracts could be increased with improvement diss...

Molecular docking and quantum chemistry calculations were used to establish the molecular model of β-cyclodextrin inclusion complex with five major compounds found in Thai sweet basil (Ocimum basilicum) essential oils, which includes linalool, eugenol, methyl eugenol, estragole, and eucalyptol. The electronic structures and the binding energies of 1:1 inclusion complexes of host:guest ratio for...

A novel synthetic methodology, employing a combination of the strain-promoted azide-alkyne cycloaddition and maleimide-thiol reactions, for the preparation of permethylated β-cyclodextrin-linker-peptidyl conjugates is reported. Two different bifunctional maleimide cross-linking probes, the polyethylene glycol containing hydrophilic linker bicyclo[6.1.0] nonyne-maleimide and the hydrophobic 5'-d...

Inclusions of lidocaine hydrochloride in cyclodextrins were prepared to obtain stable complexes compatible for association with chlorhexidine in a new gel formulation for use in urogenital applications. Two cyclodextrins, β-cyclodextrin and methyl-β-cyclodextrin, were used for encapsulating lidocaine hydrochloride through solubilization and kneading techniques. The lidocaine-cyclodextrin comple...

Silymarin is a hepatoprotective agent, having poor water solubility and oral absorption of about 23 - 47%, leading to low bioavailability of the drug. The aim of the present study is to improve the solubility and dissolution rate and in turn the hepatoprotective activity of the drug, by formulating its inclusion complex with beta (β)-cyclodextrin, using different methods. The phase solubility a...