BACKGROUND Alpha1 anti-trypsin (α1-AT), a serine protease inhibitor synthesized in the liver, is a major circulating antiprotease that provides defense against proteolytic damage in several tissues. Its deficiency is associated with airflow obstruction. The present study aimed to explore the role of α1-AT as a biomarker of airflow performance in chronic liver disease (CLD). MATERIAL/METHODS S...

α1-Adrenergic receptors (α1-ARs), as one of the most important members of G protein-coupled receptors (GPCRs), can mediate lots of physiological responses of the sympathetic nervous system. Until now, α1-ARs have been divided into at least three subtypes, α1A, α1B, and α1D, which distribute in various tissues and organs. In this research, we designed and synthesized several napthalimide-based s...

BACKGROUND We have shown that the ouabain-sensitive α2 Na,K-ATPase is required for adrenocorticotropic hormone (ACTH)-induced hypertension and gestational blood pressure regulation. It is therefore of interest to explore whether this binding site participates in the development of other forms of hypertension, such as deoxycorticosterone acetate (DOCA)-salt using mutant mice with altered sensiti...

α1-Adrenergic receptors (α1-ARs) are important players in peripheral and central nervous system (CNS) regulation and function and in mediating various behavioral responses. The α1-AR family consists of three subtypes, α1A, α1B and α1D, which differ in their subcellular distribution, efficacy in evoking intracellular signals and transcriptional profiles. All three α1-AR subtypes are present at r...

INTRODUCTION Chronic obstructive pulmonary disease (COPD) has been recently defined as a systemic pulmonary inflammatory disease, and congenital α1 antitrypsin deficiency is one of the well-established genetic risk factors for chronic obstructive pulmonary disease. The aim of our study was to evaluate the possible associations of α1 antitrypsin with inflammatory markers - CRP, sCD14, TNF-α, sTN...

Alpha-1-proteinase inhibitor (α1-PI) is the most relevant protease inhibitor in the lung. Patients with hereditary deficiency of α1-PI suffer from an impaired hepatic synthesis of α1-PI in the liver and in consequence an insufficient concentration of the protease inhibitor in the lung followed by development of lung emphysema due to an impaired protease antiprotease balance and a local relative...

• ei, fi. e1 = 1⊗ E1, e2 = 1⊗ E2; f1 = 1⊗ F1, f2 = 1⊗ F2. • e0, f0, h0. e0 = t⊗ [F1, F2] = t⊗ E31. f0 = t −1 ⊗ [E1, E2] = t−1 ⊗ E13. h0 = [e0, f0] = −1⊗ (H1 +H2) + c = −1⊗ (E11 + E33) + c • H. H = 1⊗H ⊕ Cc⊕ Cd. Note that c is just the central element c = h0 + h1 + h2. • Π. α1 = 1 = 2, α1(c) = α1(d) = 0 α2 = 1 = 2, α1(c) = α1(d) = 0 θ = α1 + α2 = 1 − 3, θ(c) = θ(d) = 0 δ : δ(1⊗H) = δ(c) = 0, δ(d...