BACKGROUND During normal pregnancy, changes in thyroid function are well documented; however, information regarding thyroid function in preeclampsia is scanty. AIM The present study was planned to study thyroid hormones in mild and severe preeclamptic women and normotensive women and correlate them with outcome of pregnancy. SUBJECT AND METHODS Thyroid hormones were analyzed in mild (n = 50...

OBJECTIVE To measure cytokine production in ex vivo stimulated leukocyte populations of women with normal pregnancy and those with preeclampsia. METHODS Whole blood from preeclamptic and normal pregnant women was stimulated with LPS or PMA/Ca-ionophore. The percentages of IFN gamma and IL-2, 4, and 10 producing lymphocytes and NK cells and the percentages of TNFalpha, IL-1 beta, and IL-12 pro...

Hypertension is the most common medical disorder encountered during pregnancy. Hypertensive disorders are one of the major causes of pregnancy-related maternal deaths in the United States. We will present a comprehensive update of the literature pertinent to hypertension in pregnancy. The paper begins by defining and classifying hypertensive disorders in pregnancy. The normal vascular and renal...

The objective: to study the genetic aspects of pathogenesis abnormal uterine bleeding during puberty (AUB PP) and evaluate effectiveness diagnostic measures taking into account presence or absence mutations in MTHFR C677T gene.Materials methods. Sixty girls with a history AUB PP were included main group 30 healthy without consisted control group. is divided three subgroups: 1st subgroup (n=20) ...

Preeclampsia is a hypertensive condition that occurs in pregnant women whose gestational age has reached 20 weeks or after delivery who previously had normal blood pressure and increased to 140/90 mmHg more. vasospastic disease involves many systems characterized by hemoconcentration, hypertension, proteinuria >300 mg/24 hours. These symptoms can be seen during pregnancy, childbirth the puer...

Preeclampsia is a placental disease characterized by hypertension and proteinuria in pregnant women, and it is associated with a high maternal and neonatal morbidity. However, circulating biomarkers that are able to predict the prognosis of preeclampsia are lacking. Thirty-eight women were included in the current study. They consisted of 19 patients with preeclampsia (13 with severe preeclampsi...

Angiogenic factors like placental growth factor and its antiangiogenic antagonist soluble fms-like tyrosine kinase 1 (sFlt1) are closely related to the pathogenesis of preeclampsia and intrauterine growth restriction. Because it is known that altered maternal sFlt1 and placental growth factor levels are detectable weeks before the onset of these pregnancy complications, it was the aim of the st...

Preeclampsia, a cardiovascular disorder of late pregnancy, is characterized as a low-renin hypertensive state relative to normotensive pregnancy. Because other nonpregnant low-renin hypertensive disorders often exhibit and are occasionally dependent on elevated arginine vasopressin (AVP) secretion, we hypothesized a possible use for plasma AVP measurements in the prediction of preeclampsia. Cop...

Preeclampsia is a pregnancy-specific syndrome manifested by the onset of hypertension and proteinuria after the 20th week of gestation. Abnormal placenta development has been generally accepted as the initial cause of the disorder. Recently, microRNA-210 (miR-210) has been found to be upregulated in preeclamptic placentas compared with normal placentas, indicating a possible association of this...

background: preeclampsia is a pregnancy complication with unknown etiology and its incidence is associated with genetic and environmental factors. there are inconsistent reports related to the role of endothelial nitric oxide synthase (enos) 4a/b polymorphism on the risk of preeclampsia development. the aim of the present study was to investigate the possible influence of enos 4a/b and its syne...