Interferons (IFNs), first recognised because of their antiviral properties, are a key defence mechanism involved in the control of virus infections. They are small proteins separated by nucleated cells in response to viral infection or other appropriate stimuli, and are thought to act principally on other cells in their immediate vicinity. They are divided into two types: type 1 comprises IFN-á...

Interferons (IFNs), first recognised because of their antiviral properties, are a key defence mechanism involved in the control of virus infections. They are small proteins separated by nucleated cells in response to viral infection or other appropriate stimuli, and are thought to act principally on other cells in their immediate vicinity. They are divided into two types: type 1 comprises IFN-á...

Interferons (IFNs), first recognised because of their antiviral properties, are a key defence mechanism involved in the control of virus infections. They are small proteins separated by nucleated cells in response to viral infection or other appropriate stimuli, and are thought to act principally on other cells in their immediate vicinity. They are divided into two types: type 1 comprises IFN-á...

Interferons (IFNs), first recognised because of their antiviral properties, are a key defence mechanism involved in the control of virus infections. They are small proteins separated by nucleated cells in response to viral infection or other appropriate stimuli, and are thought to act principally on other cells in their immediate vicinity. They are divided into two types: type 1 comprises IFN-á...

Interferons (IFNs), first recognised because of their antiviral properties, are a key defence mechanism involved in the control of virus infections. They are small proteins separated by nucleated cells in response to viral infection or other appropriate stimuli, and are thought to act principally on other cells in their immediate vicinity. They are divided into two types: type 1 comprises IFN-á...

C —¿ > T transitions at CpG sites are the most prevalent mutations found in the p53 tumor suppressor gene in human colon tumors and in the germline (Li-Fraumeni syndrome). All of the mutational hot spots are methylated to 5-methylcytosine, and it has been hypothesized that the majority of these mutations are caused by spontaneous hydrolytic deamination of this base to thymine. We have previou...

The Chow ring of a smooth algebraic variety V , denoted CH∗(V ), is an analogue of the cohomology ring that is more closely related to the algebraic, rather than topological, aspects of the variety. For a d-dimensional abelian variety A over a field k, let  = Pic(A) be its dual, the variety parameterising principal line bundles on A, and for a ∈  denote the line bundle parameterised by a as L...