Abstract Introduction Circadian disruptions are associated with increased risk for morbidity and mortality. However, it is unclear whether these associations vary by race/ethnicity. We aim to explore, 1) Examine rest-activity rhythm (RAR) patterns across race/ethnicity among a representative sample of the US adult population, 2) interaction sex in RAR patterns. Methods The study was based on Na...

background: nowadays, the first step in treatment of ectopic pregnancy (ep) is medical treatment. medical treatment with methotrexate (mtx) for ep is safe and effective method without the risks associated with the surgical procedure. but there are controversies between studies for which patients will respond better to medical treatment. objective: the aim of the present study was to investigate...

aortic aneurysm is a rare but potentially lethal complication during pregnancy. in this article we described a 30-year-old woman with a large size descending aorta aneurysm (11 cm in length and 5.6 cm in its greatest diameter), who had two term uncomplicated pregnancies. the patient received prophylactic ß-blocker drug during her second pregnancy. both pregnancies were terminated by caesarean s...

background: wet cupping therapy is a complementary therapy in pain management. the mechanism of this therapy, however, needs further elucidation. cells injured by wet cupping therapy seem to stimulate the expression of heat shock protein 70 (hsp70). its benefit in pain reduction could be mediated by the expression of ß-endorphin. this study aimed at determining the correlation between hsp70 and...

ß-defensins are a large family of cationic peptides with antimicrobial activities in vitro against Gram-positive and Gramnegative bacteria, fungi, and enveloped viruses [1]. As such, they are thought to be an important component of the innate immune system and are expressed by cells such as phagocytes and epithelia that are involved in host defence against microbial infections. The defensins fo...

Embryonic neural crest cells contribute to the development of the craniofacial mesenchyme, forebrain meninges and perivascular cells. In this study, we investigated the function of ß-catenin signaling in neural crest cells abutting the dorsal forebrain during development. In the absence of ß-catenin signaling, neural crest cells failed to expand in the interhemispheric region and produced ectop...

Spinal cord injury results in permanent sensorimotor loss in mammals, in part due to a lack of injury-induced neurogenesis. The regeneration of neurons depends upon resident neural progenitors, which in zebrafish persist throughout the central nervous system as radial glia. However the molecular mechanisms regulating spinal cord progenitors remain uncharacterized. Wnt/ß-catenin signaling is nec...

Aging promotes endothelial dysfunction, defined as a reduction in bioavailable nitric oxide (NO) produced by the endothelial isoform of nitric oxide synthase (NOS3). This enzyme is critically regulated by phosphorylation by protein kinase B (Akt), which in turn is regulated by the lipid phosphatase, PTEN. The present series of studies demonstrated a reduction in bioavailable NO as the age of ra...

AIM The objective of this study was to evaluate the prognostic value of ARID1A, p53, p21, p16 and ß-Catenin in endometrioid and clear cell ovarian and endometrial carcinomas. MATERIALS AND METHODS 97 tumors were available for analysis of ARID1A, p53, p21, p16 and ß-Catenin with the techniques of tissue microarray and immunohistochemistry. 32 were ovarian carcinomas and 65 were endometrial car...