The study aimed to evaluate the genetic diversity of eight brinjal (Solanum melongena L.) genotypes including wild species and develop a molecular profile using 14 SSR primers. value similarity matrix ranged from 0.12–0.87. Dendrogram image is revealing relationship among brinjal. super cluster divided into two clusters A B at Jaccard’s coefficient 0.31. Cluster again divide sub A1 A2 0.45. con...

OBJECTIVES In 2013, the Swiss Medical Board (SMB) concluded that for three breast cancer screens over 13 years in Switzerland, cost-effectiveness was negative, with no additional benefits in quality-adjusted life-years gained. We compared these suggested predicted effects with other estimates. METHODS We used an extensively validated model on the natural history of breast cancer in Switzerlan...

Physically based projections of the Greenland ice sheet contribution to future sea-level change are subject to uncertainties of the atmospheric and oceanic climatic forcing and to the formulations within the ice flow model itself. Here a higher-order, three-dimensional thermomechanical ice flow model is used, initialized to the present-day geometry. The forcing comes from a high-resolution regi...

PURPOSE The literature and experience of high-dose-rate (HDR) surface mould brachytherapy (SMB) in head and neck cancer is sparse. We report our institutional experience of SMB for such tumours. MATERIAL AND METHODS Thirty-five patients with malignant localized early T1/T2, N0 (21 intra-oral and 14 skin) tumours treated with SMB during 2008-2014 were analyzed. Treatment was delivered using HD...

Tudor containing protein 6 (TDRD6) is a male germ line-specific protein essential for chromatoid body (ChB) structure, elongated spermatid development and male fertility. Here we show that in meiotic prophase I spermatocytes TDRD6 interacts with the key protein arginine methyl transferase PRMT5, which supports splicing. TDRD6 also associates with spliceosomal core protein SmB in the absence of ...

In this paper, a moving horizon state and parameter estimation (MHE) scheme for the Varicol process is presented. The Varicol process is an extension of the Simulated Moving Bed (SMB) process that realizes non-integer column distributions over the separation zones by an asynchronous switching of the inlet and outlet ports (the ports are shifted individually). These additional degrees of freedom...

Simulated moving bed (SMB) chromatography has been widely studied in past and there have been various operating schemes proposed for efficient separation of binary mixtures. SMB is a promising option of separation because of its capability to achieve efficient separation even when the components differ very little in terms of affinity towards the stationary phase. However, separation of a terna...

Outputs from the regional climate model Modèle Atmosphérique Régionale at a spatial resolution of 25 km are used to study 21st century projected surface mass balance (SMB) over six major drainage basins of the Greenland ice sheet (GrIS). The regional model is forced with the outputs of three different Earth System Models (CanESM2, NorESM1 and MIROC5) obtained when considering two greenhouse gas...

The voltage-gated potassium channels of the KV7 family (KV7.1-5) play important roles in controlling neuronal excitability and are therefore attractive targets for treatment of CNS disorders linked to hyperexcitability. One of the main challenges in developing KV7 channel active drugs has been to identify compounds capable of discriminating between the neuronally expressed subtypes (KV7.2-5), a...

Smooth muscle myosin heavy chains (MHCs), the motor proteins that power smooth muscle contraction, are produced by alternative splicing from a single gene. The smooth muscle MHC gene is capable of producing four isoforms by utilizing alternative splice sites located at the regions encoding the carboxy terminus and the junction of the 25- and 50-kDa tryptic peptides. These four isoforms, SM1A, S...