Overexpression of HIF-1α, a transcription factor responsive to hypoxia, is frequently observed in malignant tumors, which sometimes show resistance to chemotherapy and radiation therapy. Consequently, decrease of HIF-1α through virotherapy offers a logical strategy for the treatment of aggressive tumors. In this study, we found that infection with the oncolytic H-1 parvovirus decreased HIF-1α p...

Cut-out data from 2,550 steer carcasses representing British, Continental and Zebu breeding were analyzed to evaluate yield grade classes based on three equations: 1) Ya = 2.5 + .984 AFT + .0084 HCW - .05 REA + .2 KPF; 2) Yb = same as Ya with intercept changed to 3.2 and KPF deleted; 3) Yc = 3.0 + .984 AFT + .0041 HCW - .03 REA, as proposed by USDA in 1984; where AFT = adjusted fat thickness (c...

This is a short and very elementary introduction to causal inference in social science applications targeted to machine learners. I illustrate the techniques described with examples chosen from the economics and marketing literature. 1 A motivating problem 1 Suppose you are given some data on ad spend and product sales in various 2 cities and are asked to predict how sales would respond to a co...

Many Constraint Programming models use integer cost variables aggregated in an objective criterion. In this context, some constraints involving exclusively cost variables are often imposed. Such constraints are complementary to the objective function. They characterize the solutions which are acceptable in practice. This paper deals with the case where the set of costs is a sequence, in which h...

PURPOSE The prostate-specific membrane antigen (PSMA) is a surface glycoprotein overexpressed on malignant prostate cells, as well as in the neovasculature of many tumors. Recent efforts to target PSMA for imaging prostate cancer rely on suitably functionalized low-molecular-weight agents. YC-27 is a low-molecular-weight, urea-based agent that enables near-infrared (NIR) imaging of PSMA in vivo...

The performance of a container terminal depends on many aspects of operations. This paper focuses on the optimal sequencing of a yard crane (or YC for short) for serving a fleet of vehicles for delivery and pickup jobs. The objective is to minimize the average vehicle waiting time. While heuristic algorithms could not guarantee an optimal solution, a conventional mathematical formulation such a...

Large forces are the primary mechanism of injury in muscular dystrophy, and muscular dystrophy is especially damaging to type IIB muscle fibers. It was hypothesized that post-tetanic potentiation (PTP) would be down-regulated to prevent damage in Xlinked muscular dystrophy (mdx) mice since PTP increases force and PTP effects are greatest in IIB fibers. PTP experiments were performed on the exte...

This study examined the impact of irrelevant dimensional variation on rule-based category learning in patients with Parkinson's disease (PD), older controls (OC), and younger controls (YC). Participants were presented with four-dimensional, binary-valued stimuli and were asked to categorize each into one of two categories. Category membership was based on the value of a single dimension. Four e...