The superoxide radical O2.-, whether produced by the xanthine/xanthine oxidase reaction or infused as KO2, solubilized by a crown ether in dry dimethyl sulphoxide, initiated a free-radical chain oxidation of anionic 2-nitropropane. Superoxide dismutase, but not catalase, inhibited oxidation of the nitroalkane. Xanthine oxidase suffered a syncatalytic inactivation, during the co-oxidation of 2-n...

Baicalein, a natural flavonoid, is structurally advantageous for binding to xanthine oxidoreductase. In our study, molecular docking analysis and Surface Plasmon Resonance revealed a direct interaction between baicalein and xanthine oxidoreductase. Moreover, 50 mg/kg/d baicalein treatment significantly suppressed the viability of xanthine oxidoreductase in hyperuricemia mouse model. The data sh...

Certain proAB deletion mutants of Salmonella typhimurium were found to be simultaneously deleted in a gene required for the utilization of guanine and xanthine (designated gxu). These mutants were resistant to 8-azaguanine and when carrying an additional pur mutation were unable to use guanine or xanthine as a purine source. The defect was correlated with deficiencies in the uptake and phosphor...

A critical reviews on molecular spectroscopic work on the palladium (II) complexes with xanthine, caffeine, theobromine, and theophyline at normal and high external pressure is presented. The methods for high external pressure measurement with the aid of Diamond Anvil Cell and Raman Measurements are also reported. *Corresponding author: [email protected] Part –I: SPECTROSCOPIC STUDIES ON PALLAD...

Some medicinal plants from Papua have been used traditionally as hyperuricemia and antioxidant agents for many ethnic in Islands. The present study aims to evaluate inhibitory xanthine oxidase, antioxidative activities, total phenolic, flavonoid of five selected plants, Myrmecodia beccarii , Villebrunea rubescens Breynia cernua Bridelia spp. Dodonaea viscosa . Preliminary phytochemical screenin...

In this lecture, evidence is presented to support the following hypothesis regarding the roles of xanthine oxidase-derived oxidants and granulocytes in ischemia-reperfusion-induced microvascular injury. During the ischemic period, ATP is catabolized to yield hypoxanthine. The hypoxic stress also triggers the conversion of NAD-reducing xanthine dehydrogenase to the oxygen radical-producing xanth...

A recent finding from this laboratory indicated that the incubation in vitro of purified xanthine oxidase with trace amounts of l-ascorbic acid resulted in a marked inhibition of the enzymatic activity (1, 2). Since the physiological mode’of action of Z-ascorbic acid is still obscure, it seemed desirable to determine whether ascorbic acid would, in the intact animal, exert a similar effect on x...

Correction for ‘WS 2 quantum dots harvesting via sonication assisted liquid exfoliation the electrochemical sensing of xanthine’ by Arunkumar Sakthivel et al. , New J. Chem. 2022, 46 17066–17072, https://doi.org/10.1039/D2NJ03446H.

There is ample evidence in the literature concerning the labile nature of rat liver xanthine oxidase and its dependence on dietary protein. McQuarrie and Venosa (1) observed a large drop in the enzyme activity when the protein content of the ration was reduced from 25 to 10 per cent. Miller (2) noticed that a 7 day inanition caused a loss of xanthine oxidase activity in rat liver which exceeded...