Although the number of available protein sequences is growing exponentially, functional protein annotations lag far behind. Therefore, accurate identification of protein functions remains one of the major challenges in molecular biology. In this study, we presented a novel approach to predict mouse protein functions. The approach was a sequential combination of a similarity-based approach, an i...

This work puts forward the theoretical observation that open circuit voltage (V oc ) loss at illuminated wide band gap side of a PN heterostructure is directly proportional to discontinuity heterostructure. photovoltage an effect photocarrier confinement and cannot be detected device terminals as separate measurable voltage. Wrongly illuminating heterojunction solar cell results in excess build...

BACKGROUND The Modified Early Warning Score (MEWS) was developed to timely recognise clinically deteriorating hospitalised patients. However, the ability of the MEWS in predicting serious adverse events (SAEs) in a general hospital population has not been examined prospectively. The aims were to (1) analyse protocol adherence to a MEWS protocol in a real-life setting and (2) to determine the pr...

“What should we think about researchers who use the wrong techniques (either wilfully or in ignorance), use the right techniques wrongly, misinterpret their results, report their results selectively, cite the literature selectively, and draw unjustified conclusions? We should be appalled. Yet numerous studies of the medical literature, in both general and specialist journals, have shown that al...

In high-throughput molecular profiling studies, genotype labels can be wrongly assigned at various experimental steps; the resulting mislabeled samples seriously reduce the power to detect the genetic basis of phenotypic variation. We have developed an approach to detect potential mislabeling, recover the "ideal" genotype and identify "best-matched" labels for mislabeled samples. On average, we...

UNLABELLED I propose a new application of profile Hidden Markov Models in the area of SNP discovery from resequencing data, to greatly reduce false SNP calls caused by misalignments around insertions and deletions (indels). The central concept is per-Base Alignment Quality, which accurately measures the probability of a read base being wrongly aligned. The effectiveness of BAQ has been positive...

abstract radiation, water and co2 are three major resources requirement for crops growth and development and within a wide range, increasing each of them would increase the biosphere productivity. higher usage of fossil fuels is increasing the atmospheric co2 and according to known crop physiological functions, such conditions should increase the crops production. however there is a possibility...

[ 117 ] Caesarean section is a life-saving procedure firmly ensconced in obstetric practice. With the advances in anaesthetic services and improved surgical techniques, the morbidity and mortality of this procedure have come down considerably. This has, albeit wrongly, emboldened obstetricians to perform more and more Caesarean sections, generating a universal upswing that has hit both developi...