Cache memory design in embedded systems can take advantage from the analysis of the software that runs on that system, which usually remains the same for its whole life. Programs can be characterized, in respect of the memory hierarchy, using locality analysis. We propose an environment which permits to analyze the locality of a program and the effects on the target system performance. The stud...

The long-held hope that vaccination strategies might be effective against cancer has motivated numerous attempts over the past century to put the idea to test in the clinic. Although the generally disappointing results have cast a long shadow over the field, advances in cancer immunology growing on the remarkable insights from basic immunology provide a strong foundation and powerful new tools ...

During the last decade, the Web has changed from a simple hyper textual repository of documents to a powerful communication media. This shift has made Web applications highly suitable for the support of educational activities, which often include collaborative sessions. However, e-learning groupware technologies are still not supported by established evaluation methodologies. Basing on previous...

We define collaborative commentary as the involvement of a research community in the interpretive annotation of electronic records. The goal of this process is the evaluation of competing theoretical claims. The process requires commentators to link their comments and related evidentiary materials to specific segments of either transcripts or electronic media. Here, we examine current work in t...

Collaborative Working Environments – Group Needs Approach to Designing Systems for Supporting Spatially Distributed Groups Collaboration in spatially distributed groups requires technological support for mediating collaborative activities and members’ interactions over time and distance. Technology provides multiple tools for supporting individual, social and task requirements of collaborative ...

The question “what is the object of socio-technical design and who is in charge of designing which aspects?” is generally described as a wicked problem which requires deliberate reflection – in theory as well as practice. Baxter’s and Sommerville’s differentiation between the development and change process and the development and change team provides a good basis for analysis. By reflecting on ...

Clinical research requires a secure working environment for data management tasks. Traditionally, this was achieved by using closed systems not accessible via network communication. More recently, however, as research projects especially in the academic setting take on more distributed forms with partners working in different institutions and/or locations, closed environments may no longer be f...

The main purposes of this study were to select a photochromic dye and to develop an active welding filter with a photochromic layer. A series of functionalized spirobenzopyranoindolins were synthesized and their photophysical and photochemical properties were investigated in a solution using absorption and emission spectroscopy. Time-resolved fluorescence spectroscopy measurements were used to ...