OBJECTIVE To examine the spontaneous blink rate over a 3-year period and its clinical and cognitive correlates among patients with first-episode schizophrenia. METHODS This study prospectively followed 93 patients with first-episode schizophrenia, schizophreniform and schizoaffective disorders for 3 years. Patients were longitudinally assessed for blink rate, their positive and negative sympt...

Recently (Roca et al. (2010), we used the relationship with general intelligence (Spearman's g) to define two sets of frontal lobe or "executive" tests. For one group, including Wisconsin card sorting and verbal fluency, reduction in g entirely explained the deficits found in frontal patients. For another group, including tests of social cognition and multitasking, frontal deficits remained eve...

AIM The purpose of this study was to elucidate determinants of quality of life (QOL) in anorexia nervosa (AN) patients. METHODS Twenty-one female patients with AN participated in the study. QOL was assessed with the 36-Item Short Form Health Survey (SF-36), and cognitive function was evaluated using the Wisconsin Card Sorting Test Keio version, the Rey Complex Figure Test, and the Social Cogn...

There is considerable evidence from animal studies that gonadal steroid hormones modulate neuronal activity and affect behavior. To study this in humans directly, we used H215O positron-emission tomography to measure regional cerebral blood flow (rCBF) in young women during three pharmacologically controlled hormonal conditions spanning 4-5 months: ovarian suppression induced by the gonadotropi...

AIMS/INTRODUCTION The aim of the present research was to study the ghrelin level, executive function and their possible association in patients with type 2 diabetes mellitus. MATERIALS AND METHODS A total of 370 people were recruited between March 2015 and March 2016 in this study. Among them, 212 participants were patients with type 2 diabetes mellitus and 158 participants were included as t...

AIM The present study aimed to compare cognitive signs of bipolar disorder patients with that of adult attention-deficit/hyperactivity disorder (ADHD) patients. METHOD The study comprised 66 bipolar disorder patients, 63 ADHD patients, and 58 healthy controls.Structured Clinical Interview for DSM-IV Axis-I Disorders (SCID-I), Wender Utah Rating Scale, and Adult Attention-Deficit/Hyperactivity...

UNLABELLED Few studies have examined the involvement of specific subregions of the prefrontal cortex in complex regional pain syndrome (CRPS). We analyzed cortical thickness to identify morphologic differences in local brain structures between patients with CRPS and healthy control subjects (HCs). Furthermore, we evaluated the correlation between cortical thickness and neurocognitive function. ...

The problem of depression among patients with Ischemic Heart Disease (IHD) especially after myocardial infarction (MI) is well documented. Various levels of cognitive dysfunctions also constitute a frequent problem in the clinical picture of IHD. The association of the two can be especially dangerous for the process of treatment and rehabilitation. The study group consisted of 111 patients aged...

OBJECTIVE Individuals with schizophrenia show severe deficits in their ability to decode emotions based upon vocal inflection (affective prosody). This study examined neural substrates of prosodic dysfunction in schizophrenia with voxelwise analysis of diffusion tensor magnetic resonance imaging (MRI). METHOD Affective prosodic performance was assessed in 19 patients with schizophrenia and 19...

Animal models of menopause have been used to further define the cognitive processes that respond to hormone therapy and to investigate parameters that may influence the cognitive effects of estrogen. Many investigations in animals have focused on memory; however, the effects of hormone therapy on executive function and attention processes have not been well studied. Thus, the purpose of this se...