Progress in gene sequencing could make rapid whole genome sequencing of individuals affordable to millions of persons and useful for many purposes in a future era of genomic medicine. Using the idea of $1000 genome as a focus, this article reviews the main technical, ethical, and legal issues that must be resolved to make mass genotyping of individuals cost-effective and ethically effective. It...

Whole genome sequencing has revealed that most cases of tuberculosis in a high-incidence setting in Malawi were caused by just one lineage of the bacterium responsible for the disease.