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ADJUVANTS, PRESERVATIVES AND TISSUE FIXATIVES IN VACCINES V contain a number of substances which can be divided into the following groups: 1. Micro-organisms, either bacteria or viruses, thought to be causing certain infectious diseases and which the vaccine is supposed to prevent. These are whole-cell proteins or just the broken-cell protein envelopes, and are called antigens. 2. Chemical subs...

OBJECTIVES We assessed the knowledge and awareness of cervical cancer, HPV and HPV vaccine, and willingness and acceptability to vaccinate in sub-Saharan African (SSA) countries. We further identified countries that fulfill the two GAVI Alliance eligibility criteria to support nationwide HPV vaccination. METHODS We conducted a systematic review of peer-reviewed studies on the knowledge and aw...

Emergence of drug-resistant strains of the pathogen Mycobacterium tuberculosis (Mtb) and the ineffectiveness of BCG in curtailing Mtb infection makes vaccine development for tuberculosis an important objective. Identifying immunogenic CD8+ T cell peptide epitopes is necessary for peptide-based vaccine strategies. We present a three-tiered strategy for identifying and validating immunogenic pept...

Current acellular pertussis vaccines have various shortcomings, which may contribute to their suboptimal efficacy and waning immunity in vaccinated populations. This calls for the development of new pertussis vaccines capable of inducing long-lived protective immunity. Immunization with whole cell pertussis vaccines and natural infection with Bordetella pertussis induce distinct and more protec...

Low levels of reporting indigenous status to the Australian Childhood Immunisation Register (ACIR) in the past have resulted in reduced confidence in vaccination coverage data for Aboriginal and Torres Straight Islander children. This study shows that the reporting of indigenous status has improved from 42% of the estimated national cohort of Indigenous children aged 12 to 14 months in 2002 to ...