System administrators are under pressure to do more work and provide better customer service with fewer staff members. At the same time, other challenges emerge: constant interrupts, poor morale, career development needs. At Intel Online Services, we use peer certification to reduce system and network administration burdens while simultaneously improving both customer service and staff morale. ...

Failure of white adipose tissue to appropriately store excess metabolic substrate seems to underpin obesity-associated type 2 diabetes. Encouraging "browning" of white adipose has been suggested as a therapeutic strategy to help dispose of excess stored lipid and ameliorate the resulting insulin resistance. Genetic variation at the DNA locus encoding the novel proteolipid neuronatin has been as...

Ultra-low-dose opioid antagonists, when combined with opiates, increase the analgesic efficacy and duration of analgesia of the opiate. This enhanced and prolonged analgesia was recently demonstrated in a 350-patient Phase II clinical trial of Oxytrex, a novel drug candidate that combines oxycodone with an ultra-low dose of the opioid antagonist naltrexone. Extensive preclinical data also show ...

Shapelets are discriminative time series subsequences that allow generation of interpretable classification models, which provide faster and generally better classification than the nearest neighbor approach. However, the shapelet discovery process requires the evaluation of all possible subsequences of all time series in the training set, making it extremely computation intensive. Consequently...

Polypropylenimine (PPI) dendrimers have been widely used as effective delivery vehicles for drugs and nucleic acids during the past decade. However, biomedical applications of PPI dendrimers were limited because of their serious cytotoxicity and low drug loading capacity. In the present study, acetylated PPI dendrimers with different degrees of acetylation ranging from 14.2% to 94.3% were synth...

Voice over Internet Protocol (VoIP) offers a wide range of benefits to both enterprises and communications & network service providers. It provides an alternate way to make a telephone call as compared to the Public Switched Telephone Network (PSTN). The industry is slowly recognizing the potential of Voice over IP and many VOIP applications have been developed in the last ten years. This paper...

The technology of functional Magnetic Resonance Imaging (fMRI) based on Blood Oxygen Level Dependent (BOLD) signal has been widely used in clinical treatments and brain function researches. The BOLD signal has to be preprocessed before being analyzed using either functional connectivity measurements or statistical methods. Current researches show that data preprocessing steps may influence the ...

Case studies of three organizations participating in the Institute for Healthcare Improvement’s Triple Aim initiative shed light on how they are partnering with providers and organizing care to improve the health of a population and patients’ experience of care while lowering—or at least reducing the rate of increase in—the per capita cost of care. The organizations—CareOregon, a nonprofit mana...

BACKGROUND Leishmaniasis is a neglected endemic disease with a broad spectrum of clinical manifestations. Pentavalent antimonials have been the treatment of choice for the past 70 years and, due to the emergence of resistant cases, the efficacy of these drugs has come under scrutiny. Second-line drugs are less efficacious, cause a range of side effects and can be costly. The formulation of new ...

Lockheed Martin Advanced Technology Laboratories, in conjunction with Lockheed Martin Maritime Systems and Sensors and Lockheed Martin Aeronautics Advanced Development Programs, performed a set of experiments in cooperation with the U.S. Navy involving collaborative, unmanned surface and air vehicle mission execution. Our multi-domain, collaborative research focused on increasing the ability of...