The nature of the CH 2 Cl 2 neutral/acidic hydrolysis reaction from ambient to supercritical conditions (25 to 600°C at 246 bar) is explored. Of primary interest is the effect of the changing dielectric behavior of the water solvent over this temperature range on this reaction. Experiments reveal that significant CH 2 Cl 2 hydrolysis occurs under subcritical temperatures, while relatively littl...

SUMMARY Hipoxia, hipercapnia and pH are known to activate the chemoreceptor cell of the carotid body by inducing membrane depolarisation. It is widely accepted that stimulus-induced depolarisation is due to the inhibition of K + currents. Besides these kation currents that undoubtfully play significant role in the chemotransduction process, chemoreceptor cells also possess anion currents, which...

BACKGROUND Cutaneous leishmaniasis (CL) is treated with parenteral drugs for decades with decreasing rate cures. Miltefosine is an oral medication with anti-leishmania activity and may increase the cure rates and improve compliance. METHODOLOGY/PRINCIPAL FINDINGS This study is a randomized, open-label, controlled clinical trial aimed to evaluate the efficacy and safety of miltefosine versus p...

Nuclear DNA binding and inhibition of growth of HeLa cells in culture were determined after 24 h incubation with the ruthenium anticancer agents cis-[Cl(2)(NH(3))(4)Ru]Cl (CCR) and (ImH)trans-[(Im)(2)Cl(4)Ru] (ICR) as a function of [Ru], Po(2), and added transferrin. Consistent with the "activation-by-reduction" hypothesis, cytotoxicity and DNA binding for both complexes increased under reduced...

BACKGROUND The purpose of this study was to evaluate the levels of zinc (Zn), copper (Cu), iron (Fe) and zinc/ copper ratio in the serum of patients with cutaneous leishmaniasis in Qom Province, center of Iran. METHODS Serum levels of zinc and copper were determined by flame atomic absorption spectrophotometer and serum iron concentration was measured by using an Auto Analyzer. The study grou...

The rK39 test is a serologic assay for the rapid diagnosis of visceral leishmaniasis (VL). Serum from a North American cohort of 59 otherwise asymptomatic soldiers with cutaneous leishmaniasis (CL) was tested with the rK39 dipstick and ELISA assays, and 10.2% and 28.8% had positive results, respectively. CL is associated with a reactive rK39 assay result in some patients without clinical eviden...

Background: Cutaneous leishmaniasis (CL) is a main public health problem in Iran with a high incidence rate among children. According to numerous studies in Iranian society, the most commonly affected age group is 1–4 years. At present, we aimed to investigate the pediatric CL among children in Golestan Province in North of I...

Background: Progesterone is essential for establishing and maintaining a pregnancy. However, premature atresia of the corpus luteum (CL) or sub-optimal progesterone secretion after ovulation may result in decreased ability to establish maintain The current limitations serum hormone testing fail give complete picture production across luteal phase required

This study examined 328 CFS sera in a study with 17 CCFP, 8 Gulf War Veterans (GWV), 24 Prostate Cancer (PC), and 52 normal sera in the modified Membrane Immunobead Assay (MIA) procedure for CTX. Three hundred and twenty-eight CFS patients' sera were examined by the modified MIA with purified MAb-CTX and 91.2% gave a titre > or =1:40. 76% of the 17 CCFP sera samples and 100% of the 8 GWV sera s...