abstract cisplatin was the first of the platinum drugs. second-generation platinum derivative was carboplatin that its efficacy in the treatment of many malignancies is equal to cisplatin, and its toxicity profile is more favorable. here we report on a 50-year-old woman with a history of cervix cancer who developed a severe hypersensitivity reaction (hsr) to carboplatin. she was admitted to the...

the cross efficiency evaluation is used to performance measurement of decision making units in data envelopment analysis concept. one of the most important shortcoming of this method is existing alternative optimal solution and therefore, the efficiency scores are not unique. we are going to summarize the pervious models proposed by researchers and suggest an alternative secondary goal approach...

world apricot (prunus armeniaca l.)  production is increasing steadily due to breeding of new high yielding cultivars in different countries. more recently, breeding programs have been modified according to consumers’ demands and also improvement in resistance to diseases (sharka, monilinia etc.), frost damages, and determination of self-(in) compatibility. in this study, fourteen apricot breed...

purpose : to determine the prevalence of the uncorrected refractive errors in bojnourd students methods : in a cross-sectional study, the samples were selected proportionate to the population of the schools using stratified randomized cluster sampling. the target population was the primary and junior high school students of the city of bojnourd. visual acuity (va) (snellen chart) and cycloplegi...

culture as the philosophy of life refers to the values, norms and rules, and actual behaviorwhich is taken over by man from the past generations, and to leave it to next generation in a differentform, separates individuals belonging to the culture from individuals belonging to other cultures.each of these different attitudes describes the degree to which the culture values the past, the present...

new biodegradable network polymers containing siloxane-linked polymeric prodrugs of 5-ammino-2-hydroxybenzoic acid (5-asa) in the main chain were prepared by ter polymerization of methacrylic acid (ma), 2-hydroxyethylmethacrylate (hema), and bis (trimethylsilyloxy) methylsilane (vbm) in the presence of some new cross-linking agents.the monomers and polymers were characterized by ft-ir and 1h-nm...

b a ckground: s taphylococcus aureus (s. aureus) has remained always an important pathogen of common infections acquired in community and as  well as serious nosocomial infections. with advent of penicillins and cephalosporins, infections could be effectively treated, but with the global emergence of methicillin resistant staphylococcus aureus strains (mrsa) physicians were  again left  with li...

1,7-Heptanediol disulfamate (hepsulfam, NSC 329680) is a new anti-cancer agent which is currently undergoing phase I clinical trials. The mechanism of action of this compound is not clear at this time. We have recently shown that hepsulfam was more toxic to L1210 leukemia cells than was busulfan. Consistent with the difference in toxicity, we found that hepsulfam induced DNA interstrand cross-l...

Cross-validation is a frequently used, intuitively pleasing technique for estimating the accuracy of theories learned by machine learning algorithms. During testing of a machine learning algorithm (foil) on new databases of prokaryotic RNA transcription promoters which we have developed, cross-validation displayed an interesting phenomenon. One theory is found repeatedly and is responsible for ...

Cross-presentation is a critical process by which antigen is displayed to CD8 T cells to induce tolerance. It is believed that CD8 dendritic cells (DCs) are responsible for cross-presentation, suggesting that the CD8 DC population is capable of inducing both cross-priming and cross-tolerance to antigen. We found that cross-tolerance against intestinal soluble antigen was abrogated in C57BL/6 mi...