OBJECTIVE This study was conducted to investigate the cognitive factors that can longitudinally predict the response to treatment in patients with schizophrenia. METHODS The subjects were 49 patients with schizophrenia who were newly hospitalized in an acute psychiatry ward and had not been treated with medication for at least 8 weeks prior to the study. The symptoms and cognitive functions o...

OBJECTIVE To investigate whether risperidone improves social cognitive impairments and executive dysfunction in people with schizophrenia. METHODS Fifty-six patients who met the Diagnostic and Statistical Manual of Mental Disorders, Fifth Edition, diagnostic criteria for schizophrenia were allocated to a risperidone treatment group (RTG, n=28) and a typical antipsychotic treatment group (TATG...

Background We examined executive functions by testing cognitive flexibility, problem solving and response maintenance means of the Wisconsin Card Sorting Test (WCST) on two consecutive days. This could render performance gains obtained in second assessment Mild Cognitive Impaired (MCI) subjects, contrast to a preserved function group (Control, CTRL group). Method 17 older adults were evaluated ...

Artificial Neural Networks (ANNs), a class of machine learning technology based on the human nervous system, are widely used in such fields as data mining, pattern recognition, and system control. ANNs can theoretically learn any function if designed appropriately, however such design usually requires the skill of a human expert. Increasingly, Genetic Algorithms (GAs), a class of optimization t...

This study investigated inhibitory function in patients with Parkinson's disease (PD) by recording event-related brain potentials (ERPs) during a Go/NoGo task. Fourteen healthy volunteers and 13 patients with PD without dementia performed a cued continuous performance test that included Go and NoGo trials. The peak latency, amplitude, and topographic distributions of the ERPs to Go and NoGo sti...

This study aimed to explore the executive function of healthy elderly Chinese people. A sample of 58 healthy Chinese aged 60 and over was recruited from Guangzhou in China. They were divided into two age groups, a younger age group (aged 60-70) and an older age group (aged over 70). Executive function was measured by a battery of seven tests which were assumed to capture specific components of ...

Materials and methods Participants were 48 BD, 21 BDMD and 70 controls. All participants underwent assessment of Full Scale IQ (WAIS-R), working memory (N-back), initiation and inhibition (HSCT), cognitive set shifting and mental flexibility (WCST), memory (WMS-III), decision making and judgement (IGT), sustained attention (CPT) and interference (SCWT). Confirmation of diagnosis was made using ...