نتایج جستجو برای: water maze

تعداد نتایج: 557571  

Journal: :American journal of physiology. Regulatory, integrative and comparative physiology 2008
Chun-Min Lo Linda C Samuelson James Brad Chambers Alexandra King Justin Heiman Ronald J Jandacek Randall R Sakai Stephen C Benoit Helen E Raybould Stephen C Woods Patrick Tso

CCK acts peripherally as a satiating peptide released during meals in response to lipid feeding and centrally functions in the modulation of feeding, exploratory, and memory activities. The present study determined metabolic parameters, food intake, anxiety-like behaviors, and cognitive function in mice lacking the CCK gene. We studied intestinal fat absorption, body composition, and food intak...

2018
Song-Hee Han Sung-June Kim Young Won Yun Sang Yoon Nam Hu-Jang Lee Beom-Jun Lee

This study was performed to investigate the effect of a concentrate of fermented wild ginseng root culture (HLJG0701) on memory improvement in the scopolamine (SPL)-induced memory-deficient mouse model. Eight-week-old male ICR mice were used to evaluate the protective effect of HLJG0701 against the SPL-induced memory loss animal model. The Morris water maze test, which measures hippocampus-depe...

2012
Bong-Kwang Jung Kyoung-Ho Pyo Ki Young Shin Young Sang Hwang Hyoungsub Lim Sung Joong Lee Jung-Ho Moon Sang Hyung Lee Yoo-Hun Suh Jong-Yil Chai Eun-Hee Shin

Immunosuppression is a characteristic feature of Toxoplasma gondii-infected murine hosts. The present study aimed to determine the effect of the immunosuppression induced by T. gondii infection on the pathogenesis and progression of Alzheimer's disease (AD) in Tg2576 AD mice. Mice were infected with a cyst-forming strain (ME49) of T. gondii, and levels of inflammatory mediators (IFN-γ and nitri...

Journal: :Anesthesia and analgesia 2007
John J McAuliffe Bernadin Joseph Charles V Vorhees

BACKGROUND Exposure to hypoxia and isoflurane (Iso) before hypoxia-ischemia has been found to be neuroprotective in neonatal rats. We investigated the long-term effects of delayed preconditioning with Iso, hypoxia, or room air on motor and cognitive function in mice that had 65 min of hypoxia-ischemia on postnatal day 10. METHODS Nine-day-old C57x129T2 F1 mice received either 1.8% Iso, hypoxi...

2014
Chang-Yul Kim Gil-Yong Lee Gyu Hwan Park Jongwon Lee Jung-Hee Jang

The purpose of this study is to investigate the memory enhancing effect and underlying molecular mechanism of arabinoxylan (AX), a major component of dietary fiber in wheat against scopolamine (SCO)-induced amnesia in Sprague-Dawley (SD) rats. Diverse behavior tests including Y-maze, Morris water maze, and passive avoidance tests were performed to measure cognitive functions. SCO significantly ...

Journal: :Hormones and behavior 2015
Jia-Qing Tong Jun Zhang Ming Hao Ju Yang Yu-Fei Han Xiao-Jie Liu Hui Shi Mei-Na Wu Qing-Song Liu Jin-Shun Qi

β-Amyloid (Aβ) is the main component of amyloid plaques developed in the brain of patients with Alzheimer's disease (AD). The increasing burden of Aβ in the cortex and hippocampus is closely correlated with memory loss and cognition deficits in AD. Recently, leptin, a 16kD peptide derived mainly from white adipocyte tissue, has been appreciated for its neuroprotective function, although less is...

Journal: :Behavioural brain research 2009
Anil Kumar Samrita Dogra Atish Prakash

Aluminium is a potent neurotoxin and has been associated with Alzheimer's disease (AD) causality for decades. Prolonged aluminium exposure induces oxidative stress and increases amyloid beta levels in vivo. Current treatment modalities for AD provide only symptomatic relief thus necessitating the development of new drugs with fewer side effects. The aim of the study was to demonstrate the prote...

2011
Bhupendra Chauhan Amrendra Kumar Chaudhary

The present study was undertaken to investigate the effects of methanolic extract of Pterocarpus marsupium Roxb. on learning and memory in albino mice. Two doses of methanolic extract of P. marsupium (25 and 50 mg/kg p.o.) were administered for neurotoxicity test. The mice administered with 25 mg/kg of the extract could significantly maintain the equilibrium on the rotating rod. Elevated plus-m...

2013
Myoung Heo

1) The purpose of this study was to investigate the effects of the task-oriented training according to the application time with the change of motor and cognition function. Focal ischemic brain injury was produced in Sprague-Dawley rats (20 rats, 250±50 g) through middle cerebral artery occlusion (MCAo). Before MCAo induction, all rats were trained in treadmill training and Morris water maze tr...

2012
Di Hu Yunfeng Cao Rongrong He Na Han Zhihui Liu Lijing Miao Jun Yin

In the present study, we examined the effect of schisandrin (SCH) of Schisandra chinensis on the amyloid-beta(1-42)- (Aβ(1-42)-) induced memory impairment in mice and elucidated the possible antioxidative mechanism. Mice were intracerebroventricular (i.c.v.) injected with the aggregated Aβ(1-42) and then treated with SCH (4, 12, and 36 mg/kg body weight) or donepezil (DPZ), a reference drug (0....

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