Mechanoelectric transduction can initiate cardiac arrhythmias. To examine the origins of this effect at the cellular level, we made whole cell voltage-clamp recordings from acutely isolated rat ventricular myocytes under controlled strain. Longitudinal stretch elicited noninactivating inward cationic currents that increased the action potential duration. These stretch-activated currents could b...

dam spillways are the structures that lead rightly and safely the outflow downstream, so that the dam integrity can be guaranteed. many accidents with dams have been caused by an inadequate spillway design or insufficient capacity. to accurately respond the hydraulic spillways, designers use physical modeling for designing this kind of structures. the scale effect in the spillway modeling, as a...

More than 70,000 large dams have been built worldwide. With growing water stress and demand for energy, this number will continue to increase in the foreseeable future. Damming greatly modifies the ecological functioning of river systems. In particular, dam reservoirs sequester nutrient elements and, hence, reduce downstream transfer of nutrients to floodplains, lakes, wetlands, and coastal mar...

River dynamics and sediment budget play a crucial role in shaping geomorphic variability of river channels deltaic environments. Basin-scale human activities, including dam construction, induce alterations flow the downstream to delta, quantification source shift along fluvial-deltaic systems is often uncertain. This study analyzed regime changes typical sediment-laden system—the lower Yellow (...

Mutual entrainment effects in hot neutron-proton superfluid mixtures are studied the framework of self-consistent nuclear energy-density functional theory. The local mass currents homogeneous or inhomogeneous systems, which we derive from time-dependent Hartree-Fock-Bogoliubov equations at finite temperatures, shown to have same formal expression as ones found earlier absence pairing zero tempe...

We suggest that bubbles are the bistable hydrophobic gates responsible for the on-off transitions of single channel currents. In this view, many types of channels gate by the same physical mechanism-dewetting by capillary evaporation-but different types of channels use different sensors to modulate hydrophobic properties of the channel wall and thereby trigger and control bubbles and gating. Sp...

In this work, studies of underground gas storage (UGS) were performed on a partially depleted, naturally fractured gas reservoir through compositional simulation. Reservoir dynamic model was calibrated by history matching of about 20 years of researvoir production. Effects of fracture parameters, i.e. fracture shape factor, fracture permeability and porosity were studied. Results show...

abstract rockfill dams are a type of hydraulic control structures used to protect river bed in cases where a considerable reservoir volume is available behind these structures; it could mitigate the floods and provide a gradual depletion of incoming volume of water so that the discharge passing downstream is decreased. one of the main issues on utilizing rockfill dams is to keep its permeabilit...

We studied the membrane currents of isolated cultured brown fat cells from neonatal rats using whole-cell and single-channel voltage-clamp recording. All brown fat cells that were recorded from had voltage-gated K currents as their predominant membrane current. No inward currents were seen in these experiments. The K currents of brown fat cells resemble the delayed rectifier currents of nerve a...