نتایج جستجو برای: vp2 protein

تعداد نتایج: 1235227  

Journal: :Journal of virology 1980
O M Kew M A Pallansch D R Omilianowski R R Rueckert

Little is yet known about the nature, or extent, of the changes involved in attenuation of neurovirulent poliovirus. The tryptic comparison reported here, of coat proteins from the Sabin type 1 polio vaccine and parental Mahoney virus, provides a useful approach and affords some insight into this question. The main obstacle, separation of the labile proteins VP1 and VP2 in an intact state from ...

Journal: :Proceedings of the National Academy of Sciences of the United States of America 2004
Bärbel Kaufmann Alan A Simpson Michael G Rossmann

Human parvovirus B19 is the only parvovirus known to be a human pathogen. The structure of recombinant B19-like particles has been determined to approximately 3.5-A resolution by x-ray crystallography and, to our knowledge, represents the first near-atomic structure of an Erythrovirus. The polypeptide fold of the major capsid protein VP2 is a "jelly roll" with a beta-barrel motif similar to tha...

2010
Narender S. Maan Sushila Maan Kyriaki Nomikou Donna J. Johnson Mehdi El Harrak Hafsa Madani Hagai Yadin Serife Incoglu Kadir Yesilbag Andrew B. Allison David E. Stallknecht Carrie Batten Simon J. Anthony Peter P. C. Mertens

Epizootic haemorrhagic disease virus (EHDV) infects wild ruminants, causing a frequently fatal haemorrhagic disease. However, it can also cause bluetongue-like disease in cattle, involving significant levels of morbidity and mortality, highlighting a need for more rapid and reliable diagnostic assays. EHDV outer-capsid protein VP2 (encoded by genome-segment 2 [Seg-2]) is highly variable and rep...

Journal: :Journal of virology 1991
K Yoshimoto S Rosenfeld N Frickhofen D Kennedy R Hills S Kajigaya N S Young

We used 18 monoclonal antibodies against B19 parvovirus to identify neutralizing epitopes on the viral capsid. Of the 18 antibodies, 9 had in vitro neutralizing activity in a bone marrow colony culture assay. The overlapping polypeptide fragments spanning the B19 structural proteins were produced in a pMAL-c Escherichia coli expression system and used to investigate the binding sites of the neu...

Journal: :Journal of virology 1971
F B Johnson H L Ozer M D Hoggan

Three major structural proteins were found in adenovirus-associated virus (AAV) type 3H virions which were analyzed by sodium dodecyl sulfate-polyacrylamide gel electrophoresis. The molecular weights of the polypeptides were determined to be approximately 66,000 (VP1), 80,000 (VP2), and 92,000 (VP3). The component having a molecular weight of 66,000 comprised about 80% of the total virion prote...

2016

Canine parvovirus belongs to the genus Protoparvovirus, family Parvoviridae. The virion is non-enveloped having icosahedral symmetry of 26nm diameter. It has a single stranded negative sense genome of 5.2 kb in length. This single-stranded virus has a DNA genome and use cellular replication machinery, their rate of nucleotide substitution is closer to that of RNA viruses than to that of double-...

Journal: :Memorias do Instituto Oswaldo Cruz 2001
R F Pereira W N Paula R de C Cubel J P Nascimento

Acute human parvovirus B19 infection is followed by an antibody response to the structural proteins of the viral capsid (VP1 and VP2). We used 80 sera collected from 58 erythema infectiosum and 6 transient aplastic crisis patients to test IgM and IgG antibodies against these two proteins in an immunofluorescence assay (IFA) using Sf9 cells infected with recombinant baculovirus expressing either...

2013
Tamara Kusay Jabbar Eva Calvo-Pinilla Francisco Mateos Simon Gubbins Abdelghani Bin-Tarif Katarzyna Bachanek-Bankowska Oya Alpar Javier Ortego Haru-Hisa Takamatsu Peter Paul Clement Mertens Javier Castillo-Olivares

The protective efficacy of recombinant vaccines expressing serotype 8 bluetongue virus (BTV-8) capsid proteins was tested in a mouse model. The recombinant vaccines comprised plasmid DNA or Modified Vaccinia Ankara viruses encoding BTV VP2, VP5 or VP7 proteins. These constructs were administered alone or in combination using either a homologous prime boost vaccination regime (rMVA/rMVA) or a he...

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