The thickness of the cerebral cortex can provide valuable information about normal and abnormal neuroanatomy. High resolution MRI together with powerful image processing techniques has made it possible to perform these measurements automatically over the whole brain. Here we present a method for automatically generating voxel-based cortical thickness (VBCT) maps. This technique results in maps ...

Structural magnetic resonance imaging (MRI) studies using voxel-based morphometry (VBM) and tract-based spatial statistics (TBSS) have been inconsistent in demonstrating impairments in gray matter (GM) and white matter (WM) structures in bipolar disorder (BD). This may be a consequence of significant confounding effects of medication, illness history and selection of controls in existing studie...

Introduction: Restless leg syndrome (RLS) is a sensory-motor disorder causing chronic sleep disturbances. Currently, neuroradiological investigations such as functional MRI, voxel-based relaxometry (VBR) as well as nuclear medicine have revealed a widespread pattern of pathological changes involving cerebra, cerebella and brain stem [1-3]. Thus, underlying mechanism of RLS is not well-understoo...