Systemic sclerosis (SSc) is an autoimmune connective tissue disease characterized by small vessel vasculopathy, autoantibodies, and skin or visceral organ fibrosis (lung, oesophagus, kidney etc.) as a result of extracellular collagen deposition. The cancer risk is higher in many rheumatic diseases, including SSc. Various defined malignancies may develop in 3%-11% of patients with SSc. These sol...

derived from modified smooth muscle cells known as glomus cells. These tumors are commonly found beneath the fingernails, but also occur in many other locations and rarely in visceral organs. They may be present at birth or may also appear multiple. Glomangiomyoma is the least frequent histopathologic type of the glomus tumor, and the case on the face appears never to have been reported in the ...

Sebaceous carcinoma is a rare, aggressive adnexal tumor of unknown etiology; 75% of these tumors arise in the periocular region while 25% arise at extraocular sites. This cutaneous tumor is a diagnostic sign of Muir-Torre syndrome, a disorder associated with visceral malignancies and gene abnormalities. Patients with sebaceous carcinoma should therefore be carefully evaluated; a detailed person...

Von Hippel-Lindau (VHL) disease is an autosomal dominant disease that produces a variety of tumors and cysts in the central nervous system and visceral organs, including renal cell carcinoma (RCC). RCC in patients with VHL disease does not frequently metastasize, therefore, the response to treatment and prognosis of metastatic RCC developed in patients with VHL disease has not been reported. Su...

visceral urate deposition (visceral gout) is a common finding during post-mortem examination of poultry. rare cases of visceral gout may occur in wild birds. a rare case of visceral urate deposition in a little bittern (ixobrychus minutus) is reported here. in may 2013, carcass of a little bittern was submitted for necropsy to the clinic of poultry diseases (faculty of veterinary medicine, razi...

  Background: Tumors involving the hand skeleton are rare. However, a basic knowledge of hand tumors is necessary for every clinician. This is due to the importance of distinguishing typical benign tumors from life or limb threatening malignant ones. Methods: This study is a review of 99 cases of osseous hand tumors presented to the department of orthopedic surgery, Imam Khomeini Hospital in Te...

background gastrointestinal stromal tumors (gists) are potentially malignant tumors; however their behavior and response to treatment is dependent on the type of mutation and immunohistochemical expression of antigens. it is recommended to perform routine molecular and immunohistochemical tests in kit and platelet derived growth factor receptor alpha (pdgfra) molecules for making decision regar...

conclusions unfortunately the tumor was unresectable and just an incisional biopsy was performed. she received chemotherapy as palliative care. case presentation we presented a 56-year-old woman admitted to our center with lung emboli symptoms. transthoracic and transesophageal echocardiography (tte and tee) demonstrated very large size (more than 10 cm diameter) multilobulated mass with mobile...

A carcinosarcoma is a tumor composed of cells morphologically resembling both malignant epithelial and mesenchymal components. An 11-year-old, female, mixed-breed terrier was referred to the clinic with complaints anorexia, vomiting exercise intolerance. Clinically, tumoral masses were seen in mammary glands. During necropsy, multilobulated calcified observed several visceral organs (the liver,...