The object of this study was to evaluate the seasonality of gout in Korea. We retrospectively examined data from 330 patients seen at nine rheumatology clinics, treated with urate lowering therapy (ULT) more than one year after stopping prophylactic medication. Demographic data, clinical and laboratory features, and seasonality of gout onset and flares were collected. Season was classified in t...

Objective. We suspect that genes or loci that contribute to coronary artery disease (CAD) may also play a role in the pathogenesis of gout, since hyperuricaemia leads to gout, and serum uric acid (SUA) levels are potential risk factors for CAD. The single nucleotide polymorphism (SNP) rs1333049 (C/G) on chromosome 9p21 has been implicated in previous studies to be associated with CAD. The aim o...

Gout is a common inflammatory disease characterized by acute arthritis and hyperuricemia. A number of epidemiological studies have suggested the critical role of gout in carcinogenesis. The aim of this study was to estimate the association between gout and cancer risk by meta-analysis of all relevant studies published to date. A comprehensive literature search in PubMed and Embase databases fro...

A recent study has demonstrated that gout significantly increases the risk of death or rehospitalization in patients suffering from heart failure. The study also found that long-term use of the drug allopurinol can significantly ameliorate the risks of recurrent cardiac events in heart failure patients suffering from gout. The study was presented at the recent American Heart Association annual ...

The classical description of Gout (za lrobayplKa-f7robaypa 'the foot-pain'-Aristotle, 350 BC; Hippocrates, 430 BC) suggests that the earliest references were to the characteristic crystal synovitis of the first metatarsophalangeal joint. Antoni van Leuwenhoek published a beautiful drawing of urate crystals from a tophus in 1679. Since that time the term 'gout' has been applied to an increasingl...

INTRODUCTION The C allele of the nonsynonymous Arg265His (rs3733591) variant of SLC2A9 confers risk for gout in Han Chinese, Solomon Island and Japanese samples, with a stronger role in tophaceous gout. There is no evidence for an association with gout in Caucasian populations. In the present study, we tested rs3733591 for association with gout in New Zealand (NZ) Māori, Pacific Island and Cauc...

Eligibility for and Prescription of Urate-Lowering Treatment in PatientsWith Incident Gout in England Gout is caused by urate crystal deposition secondary to persistent hyperuricemia. Current guidelines recommenduratelowering treatment to prevent crystal deposition and encourage crystal dissolution for patients with more severe gout or concomitant conditions.1,2 However, after the first diagnos...

INTRODUCTION Gouty arthritis (gout) is primarily cared for in ambulatory care settings. Although the prevalence of gout in the US is thought to be increasing, there have been few data on this as well as temporal changes in gout medication use. METHODS We analyzed annual visit and drug utilization data from national sample surveys of physician practices and hospital outpatient clinics in the U...

BACKGROUND The aim of this systematic review and meta-analysis was to assess the possible association between gout and erectile dysfunction (ED). METHODS Studies were identified by extensively searching EMBASE, Pubmed, CENTRAL and ISI Web of Science. Four electronic databases were searched from their inception date to the latest issue (March 2016), without language restriction. Each reviewer ...

PURPOSE To evaluate the relationship between gout and age-related cataracts (ARCs). METHODS A comprehensive literature search of the PubMed and Web of Science databases was conducted to identify papers on the association between gout and cataract risk that had been published between February 1991 and January 2017. Pooled relative risks (RRs) or odds ratios (ORs) and their corresponding 95% co...