نتایج جستجو برای: viral proteins
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Coronavirus disease 2019 (COVID-19) was spread across China and affected more than 180 countries worldwide to date. SARS-CoV-2 is a beta coronavirus that shows genomic similarity with bat coronaviruses. The intermediate source in human viral transmission caused by dromedary camels for MERS-CoV civet cats SARS-CoV. Transmission of the virus from human-to-human achieved through close contact infe...
The emergence of Severe Acute Respiratory Syndrome Coronavirus 2 (SARS-CoV-2) or 2019 Novel (2019-nCoV) has put the entire globe into unrest, primarily due to unavailability specific drug against viral proteins. In last two decades world withstood many contagious disease crashes. SARS-CoV-2 and mankind in danger. It is spreading unstoppably all over world. virus evolving thus pathogenicity stra...
Infection by enveloped viruses is initiated by the fusion of viral and cellular membranes. In many cases, the viral membrane proteins that mediate fusion must undergo conformational changes to become active. Influenza hemagglutinin, for example, is activated by a dramatic conformational rearrangement, triggered by the low pH of the intracellular compartment in which fusion occurs. Structural ch...
Viral ion channels are short membrane proteins with 50-120 amino acids and play an important role either in regulating virus replication, such as virus entry, assembly and release or modulating the electrochemical balance in the subcellular compartments of host cells. This review summarizes the recent advances in viral encoded ion channel proteins (or viroporins), including PBCV-1 KcV, influenz...
Respiratory syncytial virus (RSV) is a single-stranded RNA virus that assembles into viral filaments at the cell surface. Virus assembly often depends on the ability of a virus to use host proteins to accomplish viral tasks. Since the fusion protein cytoplasmic tail (FCT) is critical for viral filamentous assembly, we hypothesized that host proteins important for viral assembly may be recruited...
Post-translational modification has long been recognized as a way in which the properties of protein molecules may be subtly altered after synthesis of the polypeptide chain is complete. Amongst the moieties most commonly encountered covalently attached to proteins are acetyl and formyl groups, phosphate groups and carbohydrates. These modifications have been a source of study for many years, b...
A new nanoscale biomolecular motor is introduced: The Viral Protein Linear (VPL) Motor. The motor is based on a conformational change observed in a family of viral envelope proteins when a virus tries to infect a cell by the process of membrane fusion. By developing similar proteins in vitro and subjecting them to appropriate conditions, similar conformational change can be observed and control...
INTRODUCTION Peroxisomes are vital cellular organelles controlling important metabolic functions like hydrogen peroxide degradation, fatty acid metabolism, gluconeogenesis, toxin degradation, etc. (Flatmark et al., 1988; van den Bosch et al., 1992; Masters, 1997; Lopez-Huertas et al., 2000). Certain human metabolic disorders such as Zellweger syndrome, neonatal adrenoleukodystrophy, infantile R...
Hepatitis C virus (HCV), which is a major causative agent of blood-borne hepatitis, has chronically infected about 170 million individuals worldwide and leads to chronic infection, resulting in development of steatosis, cirrhosis, and eventually hepatocellular carcinoma. Hepatocellular carcinoma associated with HCV infection is not only caused by chronic inflammation, but also by the biological...
Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), the virus that causes disease 2019 (COVID-19) is now leading cause of death globally. This review elaborated human immune response to SARSCoV-2 and its evasion mechanisms as well factors determine case fatality rate effective immunity using articles selected from PubMed, Medline, Google Scholar Science Direct provided an in-depth kno...
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