Abstract Background Blastic plasmacytoid dendritic cell neoplasm (BPDCN) is a rare and challenging cancer for diagnosis treatment. Accurate plays crucial role guiding appropriate treatment, typically involving high-intensity lymphoblastic leukemia regimens which include vincristine. However, the use of vincristine may be particularly limited in patients with pre-existing neuropathy or individua...

Studying the pharmacological activities of vincristine sulfate (VCR), one of the alkaloids isolated from Vinca rosea Linn. by Svoboda et al. (1), Anderson et al. (2) observed the pressor, positive chronotropic and re spiratory stimulating effects in dogs. Since no action mechanisms of these pharmacological effects were reported, the authors attempted to clarify its pressor mechanisms. Pressor e...