Vascular structures adapt to changes in blood flow by adjusting their diameter accordingly. The factors mediating this process are only beginning to be identified. We have recently established a mouse model of arterial remodeling in which flow in the common carotid artery is interrupted by ligation of the vessel near the carotid bifurcation, resulting in a dramatic reduction in vessel diameter ...

This study investigates the buckling behavior of short cylindrical shells with hemi-spherical heads subjected to hydrostatic pressure. It is assumed that the length of the cylindrical part is smaller than or equal to its diameter while its material may be dif-ferent from that of hemispherical heads. Finite element analysis was used to seek out the effect of geometric parameters such as thicknes...

A biomimetic analysis is presented in which an expression for the optimum vessel diameter for the design of minimum mass branching or vascular networks in engineering applications is derived. Agreement with constructal theory is shown. A simple design case is illustrated and application to more complex cases with branching networks of several generations discussed. The analysis is also extended...

Naylor, Louise H., Cara J. Weisbrod, Gerry O’Driscoll, and Daniel J. Green. Measuring peripheral resistance and conduit arterial structure in humans using Doppler ultrasound. J Appl Physiol 98: 2311–2315, 2005. First published February 3, 2005; doi:10.1152/japplphysiol.01047.2004.— The purpose of this study was to establish valid indexes of conduit and resistance vessel structure in humans by u...

During vessel evolution in angiosperms, scalariform perforation plates with many slit-like openings transformed into simple plates with a single circular opening. The transition is hypothesized to have resulted from selection for decreased hydraulic resistance. Previously, additional resistivity of scalariform plates was estimated to be small – generally 10% or less above lumen resistivity – ba...

BACKGROUND The usual positioning of the Doppler sample volume to assess fetal pulmonary vein flow is in the distal portion of the vein, where the vessel diameter is maximal. This study was performed to test the association of the pulmonary vein pulsatility index (PVPI) with the vessel diameter. METHODS AND RESULTS Twenty-three normal fetuses (mean gestational age, 28.6+/-5.3 weeks) were studi...

In the isolated rat middle cerebral artery (MCA) we investigated the role of nitric oxide (NO)/cGMP in the vasodilatory response to extraluminal acidosis. Acidosis increased vessel diameter from 140 +/- 27 microm (pH 7.4) to 187 +/- 30 microm (pH 7.0, P < 0.01). NO synthase (NOS) inhibition by N(omega)-nitro-L-arginine (L-NNA, 10 microM) reduced baseline diameter (103 +/- 20 microm, P < 0.01) a...

Knowledge of the relationship between structure and function of the normal pulmonary arterial tree is necessary for understanding normal pulmonary hemodynamics and the functional consequences of the vascular remodeling that accompanies pulmonary vascular diseases. In an effort to provide a means for relating the measurable vascular geometry and vessel mechanics data to the mean pressure-flow re...

OBJECTIVES The purpose of the present study was to assess coronary vasomotor response to exercise after sirolimus-eluting stent (SES) implantation. BACKGROUND Sirolimus-eluting stents have been shown to markedly reduce the incidence of angiographic and clinical restenosis. However, long-term effects of sirolimus on endothelial function are unknown. METHODS Coronary vasomotion was evaluated ...