Intracranial manifestations are a well known feature of the mucopolysaccharidoses [1] . The appearances on computed tomography (CT) have been described and include symmetric low attenuation in white matter, hydrocephalus, and enlargement of the cortical sulci and interhemispheric fissures [2, 3]. None of these features is specific. Bone marrow transplantation has been used as a method of therap...

Left ventricular non-compaction cardiomyopathy is a rare congenital cardiomyopathy that affects both children and adults. Since the clinical manifestations are not sufficient to establish diagnosis, echocardiography is the diagnostic tool that makes it possible to document ventricular non-compaction and establish prognostic factors. We report a 47-year-old woman with a history of dilated cardio...

Purpose: Surfactant proteins (SPs) are involved in the regulation of rheological properties of body fluids. Concentrations of SPs are altered in the cerebrospinal fluid (CSF) of hydrocephalus patients. The common hallmark of hydrocephalus is enlargement of the brain ventricles. The relationship of both phenomena has not yet been investigated. The aim of this study was to evaluate the associatio...

The study by St John Sutton et al 1 in this issue of Circulation provides additional information on the importance of the myocardial substrate for the genesis of cardiac arrhythmias, in this instance, ventricular arrhythmias in the postinfarction remodeled human left ventricle (LV). The authors demonstrate significant relationships between ventricular arrhythmias and LV size, mass, and function...

Aumento isolado das câmaras cardíacas no ultrassom de segundo trimestre de gestação: sempre um sinal de alerta? Congenital heart disease (CHD) is one of the leading causes of birth defects and occurs in approximately 1 in every 100 live births [1]. This condition has been attracting the attention of the medical community in terms of screening and diagnosis of CHDs. Because of the constant movem...

We examined data on the mass, area and myocardial abnormality (scar or infarction) of the right ventricular free wall (RVFW) from 1500 consecutive dissections of hearts that came to autopsy. There were 447 hearts with associated coronary and ischemic heart disease (CAD) and 826 without CAD. RVFW mass was used as an index of hypertrophy (RVH) and RVFW area was used as an index of dilatation (RVD...