conclusions: lymphatic metastasis in patients with oral and maxillofacial scc is closely related to the positive expression of vegf, mmp-9 and timp-2. mmp-9 and timp-2 can affect the progression of cancer, which is valuable for studies on oral and maxillofacial scc genes. objectives: to explore the association between expression of vegf, mmp-9 and timp-2 in oral and maxillofacial scc and clinic...

conclusions vpa and cbz treatments caused a decrease in β-catenin and vegf levels in sw480 colon cancer cell lines. these results suggest that cbz can be considered a potential antitumor drug with potencies different from vpa. methods in the present experimental study, implemented during 2014 - 2015 in iran, after incubation of cells into 96-well plates with 5,500 cells/well, the tested drugs w...

Background: Implantation is a crucial period determining the success of a full pregnancy. Endocrine disruptors such as phytoestrogens (PEs) were thought to adversely influence embryonic implantations. However, the mechanism by which they upset implantation was not fully elucidated. Aims: The effect of administering soy isoflavones on the implantation of Wistar ...

Vascular endothelial growth factors (VEGFs) are key mediator of retinal and choroidal neovascularization as well vascular leakage leading to macular edema. As such, VEGF plays an important role in mediating visually significant complications associated with common disorders such diabetic retinopathy, vein occlusion, age-related degeneration. Various drugs that inhibit (anti-VEGF therapies) have...

In this work, nanobiohybrids of plasmonic gold nanoparticles (AuNP, anti-angiogenic) and a peptide mimicking the vascular endothelial growth factor (VEGF, pro-angiogenic) were assembled scrutinized in terms physicochemical characterization, including optical properties, surface charge, chemical structure morphology bioengineered metal nanoparticles, for their potential application as multifunct...

This study aimed to investigate the effect of hypoxic preconditioning (HPC) on primary retinal ganglion cell (RGC) survival and associated mechanism, including role vascular endothelial growth factor (VEGF). Retinas were separated from enucleated eyeballs Sprague–Dawley rats postnatal days 1–4. RGCs harvested using an immunopanning-magnetic separation system maintained for 24 h in a defined med...

introduction: angiogenesis is the physiological process through which new blood vessels form from pre-existing vessels. cardiovascular endothelial factors are involved in diseases and vascular regulation.  stachys lavandulifolia belongs to the laminacea family and its hydroalcoholic extract is used as a traditional treatment to reduce pain and inflammation. the present study was conducted to ex...