نتایج جستجو برای: vasorelaxant
تعداد نتایج: 719 فیلتر نتایج به سال:
The Front Cover shows the most active molecule of a series nitrate coumarins, coumarin-7-yl-methyl nitrate, that “magically” releases nitric oxide into bloodstream, leading to vasodilatory effect. Synthesized nitrate−coumarins show potent vasodilator activity on isolated rat aortic rings deprived endothelium, with higher effect those pre-contracted phenylephrine than potassium chloride. This su...
A new indole alkaloid; neonaucline (1), along with six known compounds-Cadamine (2), naucledine (3), harmane, benzamide, cinnamide and blumenol A-were isolated from the leaves of Ochreinauclea maingayii (Rubiaceae). In addition to that of compound 1, (13)C-NMR data of cadamine (2) and naucledine (3) were also reported. Structural elucidations of these alkaloids were performed using spectroscopi...
The follow-up of phytochemical and pharmacological studies of Sida rhombifolia L. (Malvaceae) aims to strengthen the chemosystematics and pharmacology of Sida genera and support the ethnopharmacological use of this species as hypotensive herb. The present work reports phytoconstituents isolated and identified from aerial parts of S. rhombifolia by using chromatographic and spectroscopic methods...
As part of our program toward designing potassium channel openers, synthesis of a novel series of 1,5-diphenylsubstituted 1,2,3-triazoles, as potential activators of the large-conductance calcium-activated potassium channels (BK), as well as their vasorelaxant activity are presented. The functional effect of these potential structurally novel BK-openers on vascular contractile function were stu...
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