Arginine vasopressin is elevated in congestive heart failure. To determine the effect of arginine vasopressin upon systemic hemodynamics and regional blood flows, we administered the specific inhibitor of the vascular action of vasopressin [1-(beta-mercapto-beta,beta-cyclopentamethylenepropionic acid),2-(O-methyl)-tyrosine]-arginine vasopressin [d(CH2)5Tyr(Me)AVP] to 15 dogs with chronic right-...

Crit Care Resuscitation ISSN: 1441-2772 4 September 2006 8 3 239-240 © C r i t C a r e R es u s c i t a t i on 20 06 www.jficm.anzca.edu.au/aaccm/journal/publications.htm Points of view retic hormone, and is deficient in patients w shock. It is therefore being increasingly consid alternative or additional vasopressor therapy patients. Small cases series and a small pha suggest it as clinical be...

VASOPRESSIN ANATOMY OF THE MOUSE BRAIN FEBRUARY 2010 BENJAMIN D. ROOD, B.S., BATES COLLEGE M.S., UNIVERSITY OF MASSACHUSETTS AMHERST Ph.D., UNIVERSITY OF MASSACHUSETTS AMHERST Directed by: Geert J. de Vries The nine amino acid peptide vasopressin acts as a neurohormone in the periphery and a neurotransmitter / neuromodulator in the central nervous system. Historically, research on vasopressin n...

A plasma membrane fraction was prepared from pig kidney medulla. It contained lysine-vasopressin-sensitive adenylate cyclase activity (maximum activation: 4to 6fold, apparent Km value for the hormone: about 5 X 1OV M). Lysine-vasopressin was not inactivated by the membrane preparation even at low hormonal concentrations. The specific [3H]lysine-vasopressin (vasopressin) binding sites found are ...

Alzheimer's disease (AD) is the most common form of dementia in the elderly. For more effective therapy early diagnostic markers could be beneficial. Therefore we compared one year old rats with adults and examined if changes in possible brain markers of AD preceeded memory decline. We also tested if vasopressin-deficient animals were useful model of AD as vasopressin has well known positive ef...

In this study, cells derived from rat inner medullary collecting duct formed a polarized monolayer when grown in wells on a membrane. When the membrane was sealed in an Ussing apparatus, the cells passed water from their apical to basolateral surfaces in the presence of an osmotic gradient. This was detected by the movement of the meniscus (1 mm = 1 microL) in a capillary tube connected to the ...

The effects of physiological elevations in arginine vasopressin on the cardiovascular system were studied in a group of nine conscious, chronically instrumented dogs. The animals were studied under normal conditions (plasma vasopressin, 4.1 +/- 0.4 pg/ml), after 24 hours of dehydration (plasma vasopressin, 7.3 +/- 1.5 pg/ml), after a 30-minute vasopressin infusion at 2.6 ng/kg/min (plasma vasop...

The role of vasopressin in aggression received much attention in recent years. However, vasopressin has complex roles on social behavior, which are affected by social experience, motivation and hormonal background, suggesting that its effects depend on the condition of subjects. This hypothesis was tested here by studying the impact of vasopressin deficiency on aggressiveness in reproductively ...

Neuroprotective effect of vasopressin analogues, arginine Vasopressin (AVP) and lysine Vasopressin (LVP) was evaluated against MgCl2 induced cerebral ischemia model. AVP significantly prevented (P < 0.01) MgCl2 (1M) induced cerebral ischemia as compared to lysine Vasopressin (LVP) which was less effective (P < 0.05). Pretreatment with PI-3 kinase inhibitors, Wortmannin and LY-294002 (50 microg/...

In dogs anesthetized with intravenous chloralose, vasopressin was injected either intravenously or into the cerebral ventricles, and the cardiovascular effects were studied before and after stabilizing the arterial blood pressure, bilateral vagotomy, and transection of the cervical cord at the level of C2. Intravenous vasopressin caused a rise in arterial blood pressure and pronounced bradycard...