BACKGROUND: Angiosarcoma is an aggressive, malignant neoplasm of vascular or lymphatic origin. Herpes virus 8 (HHV-8) is a member of the herpes family with a tropism for endothelial cells and it has been proven to induce vascular neoplasms, such as Kaposi's sarcoma. The role of HHV-8 in the pathogenesis of angiosarcoma has not been well defined. OBJECTIVE: To investigate the relationship betw...

Carotid body tumours are benign neoplasms. This case report describes two patients with this rare tumour with diagnostic workup and treatment options. The first case was a 36-year-old gentleman who presented with 6 months history of painless swelling on the left side of neck. The second patient was 60-years-old man who presented with slowly growing swelling on the right side of neck for the las...

most common autosomal dominant genetic disorders and this inherited disease is associated with various neoplasms, skeletal and vascular abnormalities (1). The vascular lesions affecting the head and neck of patients with neurofibromatosis type 1 (NF-1) has been reported as occlusive or stenotic form, moyamoya vessel or aneurysm. However, spontaneous vertebral arteriovenous fistula (AVF) associa...

V617F driver mutation of JAK2 is the leading cause of the Philadelphia-chromosome-negative myeloproliferative neoplasms (MPNs). Although thrombosis is a leading cause of mortality and morbidity in MPNs, the mechanisms underlying their pathogenesis are unclear. Here, we identified pleckstrin-2 (Plek2) as a downstream target of the JAK2/STAT5 pathway in erythroid and myeloid cells, and showed tha...

Arteriovenous malformations (AVMs) are part of a group of vascular anomalies which can be further sub classified into neoplasms and malformations, characterized by specific morphology, pathophysiology, clinical behaviour and management. AVMs in the oral and maxillofacial region are rare but potentially life-threatening vascular lesions. Bleeding, facial asymmetry, loose teeth and headache are c...

Hemangiomas are developmental vascular abnormalities and more than 50% of these lesions occur in the head and neck region, with the lips, tongue, buccal mucosa, and palate most commonly involved. They are considered as hamartomas rather than true neoplasms. Here we report a case of hemangioma of the body of the tongue, discussing the diagnostic aspects and treatment modalities of such lesion an...

OBJECTIVES The stroma-rich variant of hyaline-vascular type of Castleman's disease (SR-HVCD) should be differentiated from vascular or follicular dendritic reticulum cell neoplasms. In this paper, we present a rare case of HVCD. We also suspect a possible association between SR-HVCD and calcifying fibrous pseudotumor. METHODS A 34-year-old man was found an abdominal mass by computed tomograph...

Although interpatient variations in the course and anatomy of extracranial internal carotid arteries (EICAs) have been described previously, intrapatient variability is rarely cited in the literature. Distance between EICAs and the pharyngeal wall is an important determinant of vascular injury risk. A retropharyngeal EICA has crucial implications in patients undergoing pharyngeal procedures, an...

P-selectin is a cell adhesion molecule that is sequestered in Weibel-Palade storage reservoirs within the vascular endothelium and alpha granules in platelets. P-selectin is rapidly translocated to the vascular lumen after tissue injury to initiate the adhesion and activation of platelets and leukocytes. We studied the histological pattern of P-selectin expression in irradiated tumor blood vess...

Cerebellar haemangioblastomas are benign neoplasms which have been reported to have a favourable prognosis. The authors report the experience of Atkinson Morley's Hospital, London with 14 cases of solid haemangioblastoma since the introduction of the CT scan. Death or a poor result occurred in 50% of cases. Incomplete excision carried a high risk of complications. The CT scan appearances were t...