Tomato ringspot nepovirus RNA-1-encoded polyprotein (P1) contains the domains for the putative NTP-binding protein, VPg, 3C-like protease and a putative RNA-dependent RNA polymerase in its C-terminal region. The N-terminal region of P1, with a coding capacity for a protein (or a precursor) of 67 kDa, has not been characterized. Using partial cDNA clones, it is shown that the 3C-like protease ca...

Formation of plant virus membrane-associated replication factories requires the association of viral replication proteins and viral RNA with intracellular membranes, the recruitment of host factors and the modification of membranes to form novel structures that house the replication complex. Many viruses encode integral membrane proteins that act as anchors for the replication complex. These hy...

PBT2 is a copper/zinc ionophore that rapidly restores cognition in mouse models of Alzheimer's disease (AD). A recent Phase IIa double-blind, randomized, placebo-controlled trial found that the 250 mg dose of PBT2 was well-tolerated, significantly lowered cerebrospinal fluid (CSF) levels of amyloid-beta42, and significantly improved executive function on a Neuro-psychological Test Battery (NTB)...

The ability of natural killer (NK) cells to kill virus-infected cells depends on the presence of ligands for activation receptors on the target cells. We found the presence of few, if any, NKp30 and NK46 ligands on T cell blasts infected with HIV, although NKp44 ligands were found on infected cells. HIV does induce the NKG2D ligands ULBP-1, -2, and -3. These ligands are involved in triggering N...

The signaling lymphocyte activation molecule (SLAM) family includes homophilic and heterophilic receptors that modulate both adaptive and innate immune responses. These receptors share a common ectodomain organization: a membrane-proximal immunoglobulin constant domain and a membrane-distal immunoglobulin variable domain that is responsible for ligand recognition. CD84 is a homophilic family me...

Penelitian ini bertujuan untuk mengetahui perspektif Otoritas perdagangan di pasar modal atas rasionalitas pengambilan keputusan keuangan investor dalam berinvestasi berdasarkan literasi dan preferensi menggunakan analisa fundamental teknikal. pendekatan kualitatif, dengan unit analisis persepsi Nusa Tenggara Barat (NTB) sebagai informan yang diambil pemahaman keuangannya. Hasil penelitian meny...

Abstract Can tax regimes shape the incentives to engage in armed conflict? Indian mining royalties benefit states but are set by central government. India's Maoist belt is mineral rich, and responsible for counterinsurgency operations. We exploit introduction of a 10% ad valorem on iron ore that increased royalty collections affected factor 10. find hike was followed significant intensification...

Experimental and theoretical investigations of the twist-bend nematic (NTB) phase in liquid crystals have recently received significant attention for reasons unusual interesting characteristics NTB. Though NTB was predicted to exist rigid bent-core LCs by Ivan Dozov 2001, nevertheless it has unambiguously been proven only a few systems so far. Here both (N) phases are investigated hockey shaped...

BACKGROUND Nasal tuberculosis (NTB) is rare, but it can be caused by either a pulmonary disease or a retrograde involvement of the nose by lupus vulgaris of the facial skin. In this study, we present a case of NTB with an ulcerative lesion in her left nasal cavity. CASE PRESENTATION A 56 years old woman presented with an ulcerative lesion in her left nasal cavity. The patient exhibited no cli...