In vivo studies are an important tool for the identification and validation of novel drug targets in medicine; however, the interpretation of submitted and published data is often compromised by inadequate study design. Different study protocols, including the number of control groups and group size calculations, differ in target identification and validation studies. Furthermore, animal studie...

There are so many ISO documents to understand and utilize for validation studies and routine control. A biological indicator (BI) is essential for conducting sterilization validation and routine control. ISO 11138-1 and ISO 14161 are the major documents to follow for BI manufacturers and BI users, respectively. In ISO 11138-1, BI manufacturers must utilize a BI with 106 CFU/carrier as an initia...

background: the gail model has been widely used for estimation of absolute risk of breast cancer development. the original model and most of the validation studies have been performed among western populations and controversial results have been reported regarding the applicability of this model in asian populations. our aim was to investigate the performance of this model in iranian women. met...

australian rainfall is related with numerous key climate predictors namely el-nino southern oscillation (enso), indian ocean dipole (iod) and southern annular mode (sam). some studies have tried to discover the effects of these climate predictors on rainfall variability of different parts of australia, particularly western australia, queensland and victoria. nonetheless, clear association betwe...

Well validated antibodies are crucial to progress in a wide range of life science disciplines, but validating an antibody is a complex and ongoing process. Antibody validation is often carried out as preliminary work to a larger study so the validation data may go unpublished and needless duplication of efforts can occur. This collection of articles in F1000Research provides a home for papers d...

OBJECTIVES Reviewing disease activity indices (DAI) in systemic sclerosis (SSc) and reporting their validation status. METHODS Literature was systematically reviewed on studies documenting the development of DAI, assessing the validation status of DAI and studies using a DAI in their analysis. The qualitative and quantitative validation status of existing DAI was assessed based on OMERACT and...