Carta aos editores BDNF and episodic memory in patients with bipolar disorder BDNF e memória episódica em pacientes com transtorno afetivo bipolar Dear Editor, Brain-derived neurotrophic factor (BDNF), a member of the neurotrophin family, has a whole brain distribution that is highly expressed in key cerebral structures related to psychiatric disorders and cognition such as the amygdala, pre-fr...

BACKGROUND According to the humor theory of Traditional Uighur Medicine (TUM), a same disease is classified into different abnormal humor types and corresponding methods are applied to treat the diseases according to the type of abnormal humor characteristics. To date the biological foundation of classification of diseases by humor theory has been little studied and the mechanism of action is s...

TO THE EDITOR Accumulating evidence suggests that brain-derived neurotrophic factor (BDNF) plays a key role in the patho-physiology of major depression, as well as the therapeutic action of antidepressants. 1,2) Serum levels of BDNF in drug naïve patients with major depression are significantly lower than those in normal controls. Additionally, serum levels of BDNF in drug naïve patients can be...