Preterm birth is the leading cause of perinatal morbidity and mortality worldwide, and is the most important challenge to modern obstetrics. A major obstacle has been that preterm birth is treated (implicitly or explicitly) as a single condition. Two thirds of preterm births occur after the spontaneous onset of labor, and the remaining one third after "indicated" preterm birth; however, the cau...

OBJECTIVES Preterm birth contributes to a range of healthcare problems amongst infants surmounting to sizeable healthcare costs. Twin pregnancies are at particular risk of preterm birth. The objective of this study was to assess the cost-effectiveness of vaginal progesterone gel for the prevention of preterm birth in twin pregnancies. METHODS An economic evaluation was conducted alongside a r...

This experiment was conducted to determine the reproductive performance of Arabian ewes treated with short and long-term progesterone devices in addition to low doses of equine chorionic gonadotropin (eCG) during the anoestrus season. A total of 36 ewes were divided into three groups: in group I vaginal sponges (60 mg medroxy progesterone acetate; (MAP)) were applied and removed after 6 days; i...

INTRODUCTION Luteal phase support in assisted reproductive technology (ART) cycles is still controversial. The present study was conducted to evaluate the effect of adding oral oestradiol to progesterone during ART cycles. MATERIAL AND METHODS In this prospective case control study, infertile women under 35 years old who were candidates for IVF/ICSI cycles in Royan Institute were enrolled. A ...

BACKGROUND Progesterone may be effective in prevention of premature birth in some high risk populations. Women with arrested premature labor are at risk of recurrent labor and maintenance therapy with standard tocolytics has not been successful. METHODS Randomized double blinded clinical trial of daily treatment with 200 mg vaginal progesterone in women with arrested premature labor and an up...

Recently, weak estrous behavior was assumed to be the cause of a decline in breeding efficiency in cattle. The present study investigated the effect of measuring the vaginal temperature on the detection of estrus in Japanese Black cows. First, the effect of hormone administration to cows with a functional corpus luteum on the vaginal temperature was evaluated by continuous measurement using a t...

BACKGROUND Progesterone prepares the endometrium for pregnancy by stimulating proliferation in response to human chorionic gonadotropin (hCG), which is produced by the corpus luteum. This occurs in the luteal phase of the menstrual cycle. In assisted reproduction techniques (ART) the progesterone or hCG levels, or both, are low and the natural process is insufficient, so the luteal phase is sup...

Background: Preterm labour is a major health challenge in obstetrics. Many risk factors being identified, the most common one short cervical length, can be diagnosed by transvaginal ultrasound scan after 13 weeks of pregnancy. Vaginal progesterone bioavailable form that have effect on uterine and cervix. Progesterone found to inhibit production proinflammatory cytokines prostaglandins within ut...

Article history: Received 10 April 2017 Accepted 10 April 2017 Available online 13 April 2017 delivery. The researchers also showed that treatment interventions used for PTB prevention can impact upon vaginal microbiota composition. For example, while vaginal progesterone supplementation has minimal impact on community composition, cervical cerclage using braided suture material strongly promot...